Yiannis Ioannou, PhD
img_Yiannis Ioannou
PROFESSOR | Genetics and Genomic Sciences
Research Topics
Alzheimer's Disease, Apoptosis/Cell Death, Atherosclerosis, Brain, Cardiovascular, Caveoloe, Diabetes, Drug Design and Discovery, Gene Regulation, Genetics, Human Genetics and Genetic Disorders, Intracellular Transport, Lipid Signaling, Lysosomal Storage Diseases, Lysosomes/endosome, Mass Spectrometry, Membrane Proteins/Channels, Membranes, Mental Retardation, Neuro-degeneration/protection, Obesity, Protein Complexes, Protein Degradation, Protein Kinases, Protein Phosphatases, Protein Structure/Function, Protein Trafficking & Sorting, Proteomics, RNA, Transporters
Multi-Disciplinary Training Area
Genetics and Genomic Sciences [GGS]

Specific Clinical/Research Interest: Molecular genetics

Summary of Research Studies:
Our lab is involved in a number of projects that center on the biology, function and diseases of the endosomal/lysosomal (E/L) system. In addition, we are developing methods to treat lysosomal diseases via enzyme and gene therapy approaches. See our website for details. Some brief examples of our work are given below: Subcellular Cholesterol/lipid Transport. Although the intercellular transport of cholesterol from the liver to peripheral tissues has been intensively studied, little is known about its egress from the E/L system, its intracellular transport and the proteins involved in this process. The existence of such proteins is highlighted by the autosomal recessive disorders, Niemann-Pick C (NPC) disease, in which cholesterol accumulates in lysosomes and leads to progressive neurodegeneration and Tangier disease in which cholesterol efflux at the plasma membrane is defective. Our overall objective is to identify and characterize the various components of the intracellular cholesterol and lipid transport machinery and determine their function and interactions. Proteomics of the E/L system. Cell Proliferation and Apoptosis: It is becoming clear that the lysosome has a greater role in cellular processes than was originally proposed. Our studies focus on the isolation and purification of intact endosomes and lysosomes. These organelles are then characterized for their membrane composition to identify novel, membrane proteins. We have established a novel method for the isolation and characterization of endosomes and lysosomes. A long-term goal is to identify all the components of the endosomal/lysosomal apparatus using 2D electrophoresis and tandem mass spectroscopy. Therapy for Diseases that Affect the CNS. Effective gene therapy strategies for the treatment of human disease still remain highly experimental due to difficulties encountered in the actual application of many gene therapy schemes. Thus, we are developing novel approaches to address these limitations. Our strategies focus on "Bypass Therapy" an approach aiming at stimulating alternate pathways to bypass a cellular block caused by a specific gene defect.

BA, Baruch College, CUNY

PhD, Mount Sinai School of Medicine


Selected Publications

Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis. Joeri W. van Straalen, Lianne Kearsley-Fleet, Jens Klotsche, Sytze de Roock, Kirsten Minden, Arnd Heiligenhaus, Kimme L. Hyrich, Joke H. de Boer, Lovro Lamot, Alma N. Olivieri, Romina Gallizzi, Elzbieta Smolewska, Enrique Faugier, Serena Pastore, Philip J. Hashkes, Cristina N. Herrera, Wolfgang Emminger, Rita Consolini, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart, G. Cleary, E. Baildam, L. Wedderburn, J. Davidson, A. Chieng, F. McErlane, H. Foster, C. Ciurtin, Y. Ioannou, W. Thomson, K. Hyrich, Tilmann Kallinich, Frank Dressler, Jasmin Kümmerle Deschner, Frank Weller-Heinemann, Gerd Horneff, Anton Hospach, Kirsten Mönkemöller, Johannes Peter Haas, Daniel Windschall, Ivan Foeldvari, Dirk Foell. Arthritis and Rheumatology

No evidence that genetic predictors of susceptibility predict changes in core outcomes in JIA. Annie Yarwood, Stephanie Shoop-Worrall, Elena López-Isac, Samantha Louise Smith, Andrew P. Morris, Eileen Baildam, Alice Chieng, Gavin Cleary, Coziana Ciurtin, Joyce E. Davidson, Helen E. Foster, Yiannis Ioannou, Flora McErlane, Lucy R. Wedderburn, Kimme Hyrich, Wendy Thomson, John David Bowes, Melissa Tordoff, Kimme L. Hyrich, Wendy Thomson, Stephen Eyre. Rheumatology

A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome. Perrine Soret, Christelle Le Dantec, Emiko Desvaux, Nathan Foulquier, Bastien Chassagnol, Sandra Hubert, Christophe Jamin, Guillermo Barturen, Guillaume Desachy, Valérie Devauchelle-Pensec, Cheïma Boudjeniba, Divi Cornec, Alain Saraux, Sandrine Jousse-Joulin, Nuria Barbarroja, Ignasi Rodríguez-Pintó, Ellen De Langhe, Lorenzo Beretta, Carlo Chizzolini, László Kovács, Torsten Witte, Barbara Vigone, Jacques Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec, Divi Cornec, Sandrine Jousse-Joulin, Bernard Lauwerys, Julie Ducreux, Anne Lise Maudoux, Carlos Vasconcelos, Ana Tavares, Esmeralda Neves, Raquel Faria, Mariana Brandão, Ana Campar, António Marinho, Fátima Farinha, Isabel Almeida, Miguel Angel Gonzalez-Gay Mantecón, Ricardo Blanco Alonso, Alfonso Corrales Martínez, Ricard Cervera, Ignasi Rodríguez-Pintó, Gerard Espinosa, Rik Lories, Ellen De Langhe, Nicolas Hunzelmann, Doreen Belz, Yiannis Ioannou. Nature Communications

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Faculty Spotlight: Yiannis Ioannou, PhD

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Ioannou has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.