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Tristan Shuman, PhD
img_Tristan Shuman
ASSOCIATE PROFESSOR | Neuroscience
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Research Topics
Alzheimer's Disease, Autism, Computational Neuroscience, Electrophysiology, Epilepsy, Extracellular Unit Recording, Hippocampus, Memory, Neuroscience, Seizure, Stem Cells, Systems Neuroscience, Transplantation
Multi-Disciplinary Training Area
Neuroscience [NEU]
Open source miniature microscopes
Miniscope.org is an online open-source platform for developing and using miniature microscopes primarily used for calcium imaging in small rodents. As a primary developer and contributor to this effort, my lab is continuing to develop new innovations of this technology and sharing them with the neuroscience community.
Cognitive Deficits Associated with Temporal Lobe Epilepsy
Epilepsy is a debilitating disorder that affects over 3 million Americans, with 30% of patients unresponsive to anti-epileptic drugs and often resorting to large resections of the brain. Therefore, it is critical to develop new therapeutic interventions to suppress seizures and cognitive deficits in epilepsy. My lab uses state of the art recording and manipulation techniques to examine how abnormal circuit processing leads to seizures and cognitive deficits in epilepsy and to understand how seizures and cognitive deficits can be suppressed with novel interventions. We use in vivo calcium imaging with miniature microscopes as well as in vivo electrophysiology with silicon probes to examine how the epileptic brain is altered in mice.
Interneuron and Network Dysfunction in Mouse Models of Alzheimer's Disease
Alzheimer’s disease (AD) is a form of dementia characterized by memory loss and progressive cognitive impairments. Memory impairments in AD increase with age and are linked to hyperexcitability, circuit remodeling, and impaired interneuron function. However, it remains unclear how changes in interneuron function contribute to cognitive deficits. My lab is using in vivo electrophysiology with silicon probes to examine how hippocampal interneuron function is altered in AD model mice and investigate whether network dysfunction in young, pre-symptomatic mice can predict future memory impairments.

PhD, University of California, San Diego

University of California, Los Angeles

2020

Shah Research Scholar

Friedman Brain Institute

2018

CURE Taking Flight Award

CURE Epilepsy

2018

AES Junior Investigator Award

American Epilepsy Society

2018

Nash Family Scholar

Friedman Brain Institute

2016

AES Young Investigator Award

American Epilepsy Society

2015

AES Grass Young Investigator Award

American Epilepsy Society

2014

Epilepsy Foundation Postdoctoral Fellowship

Epilepsy Foundation

27
Publications

Selected Publications

Only Hit the Bad Guys: A Gene Therapy Approach to Selectively Silence Highly Active Neurons Reduces Chronic Seizures in Epileptic Mice. Tristan Shuman. Epilepsy Currents

The Best Things Happen When You Least Expect Them: Responsive Neurostimulation During Low-Risk Brain States is Associated with Improved Long-Term Seizure Suppression. Paul A. Philipsberg, Tristan Shuman. Epilepsy Currents

Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer’s disease pathology. Lingxuan Chen, Zoé Christenson Wick, Lauren M. Vetere, Nick Vaughan, Albert Jurkowski, Angelina Galas, Keziah S. Diego, Paul Philipsberg, Ivan Soler, Yu Feng, Denise J. Cai, Tristan Shuman. Journal of Neuroscience

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New York, NY 10029

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Shuman has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.