Tristan Shuman, PhD
img_Tristan Shuman
Research Topics
Alzheimer's Disease, Autism, Computational Neuroscience, Electrophysiology, Epilepsy, Extracellular Unit Recording, Hippocampus, Memory, Neuroscience, Seizure, Stem Cells, Systems Neuroscience, Transplantation
Multi-Disciplinary Training Area
Neuroscience [NEU]
Open source miniature microscopes is an online open-source platform for developing and using miniature microscopes primarily used for calcium imaging in small rodents. As a primary developer and contributor to this effort, my lab is continuing to develop new innovations of this technology and sharing them with the neuroscience community.
Interneuron and Network Dysfunction in Mouse Models of Alzheimer's Disease
Alzheimer’s disease (AD) is a form of dementia characterized by memory loss and progressive cognitive impairments. Memory impairments in AD increase with age and are linked to hyperexcitability, circuit remodeling, and impaired interneuron function. However, it remains unclear how changes in interneuron function contribute to cognitive deficits. My lab is using in vivo electrophysiology with silicon probes to examine how hippocampal interneuron function is altered in AD model mice and investigate whether network dysfunction in young, pre-symptomatic mice can predict future memory impairments.
Cognitive Deficits Associated with Temporal Lobe Epilepsy
Epilepsy is a debilitating disorder that affects over 3 million Americans, with 30% of patients unresponsive to anti-epileptic drugs and often resorting to large resections of the brain. Therefore, it is critical to develop new therapeutic interventions to suppress seizures and cognitive deficits in epilepsy. My lab uses state of the art recording and manipulation techniques to examine how abnormal circuit processing leads to seizures and cognitive deficits in epilepsy and to understand how seizures and cognitive deficits can be suppressed with novel interventions. We use in vivo calcium imaging with miniature microscopes as well as in vivo electrophysiology with silicon probes to examine how the epileptic brain is altered in mice.

PhD, University of California, San Diego

University of California, Los Angeles


Shah Research Scholar

Friedman Brain Institute


CURE Taking Flight Award

CURE Epilepsy


AES Junior Investigator Award

American Epilepsy Society


Nash Family Scholar

Friedman Brain Institute


AES Young Investigator Award

American Epilepsy Society


AES Grass Young Investigator Award

American Epilepsy Society


Epilepsy Foundation Postdoctoral Fellowship

Epilepsy Foundation

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Shuman did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.