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Thomas P Zwaka, MD, PhD
img_Thomas P Zwaka
PROFESSOR | Cell, Developmental & Regenerative Biology
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Research Topics
Apoptosis/Cell Death, Cell Biology, Developmental Biology, Embryology, Epigenetics, Gene Regulation, Gene Therapy, Stem Cells, Tissue Engineering, Transcription Factors, Transcriptional Activation and Repression
Multi-Disciplinary Training Area
Development Regeneration and Stem Cells [DRS]
Molecular control of stem cells
This project seeks to clarify the molecular function Ronin, a member of the THAP (Thanatos-associated domain-containing apoptosis-associated proteins) gene family, and its biochemical role in specific cell types as they change fates. We propose that Ronin (and other THAPs) mediate promoter-promoter interactions to regulate gene transcription in a cell type-specific manner.
Developing new models for Parkinson’s disease
We have discovered methods to enhance the self-organizing properties of differentiating pluripotent cells to promote the proper development of mid-brain structures. Ultimately, we are creating patient-specific ex vivo models of PD using the methods we are developing to generate midbrain organoids from patient iPSCs. This will allow us to get a handle on the factors relevant to each individual’s unique manifestation of the disease. We are also conducting parallel screens in this system for neuroprotective small molecules.
Cell competition: Protection of early embryogenesis and pluripotent stem cells against genetic parasites through a primitive immune system
Retrotransposons can seriously damage the genome of the nascent embryo and cause sporadic diseases and infertility. Here we will explore a new sensing mechanism that involves early embryonic cells “sniffing” one another for endogenous retroviruses and the removal of cells that failed to silence their genetic parasites. Our line of investigation will provide new targets for genetic diagnosis and interventions targeting pregnancy loss, birth defects and childlessness.
Quantum biology
In this project we explore non-classical (quantum physical) properties of early embryonic cells and neurons. The idea is that the current view that cells organize activities (like signal transduction or subcellular communication) via random walks among the staggering range of possibilities is incredibly unlikely. We propose instead a quantum mechanics-based relationship between molecular assemblies and elements of cell behavior. We are currently testing the prediction that cells harbor highly specialized structures that act in a quantum-computer like fashion to orchestrate cell function at a higher level.

MD PhD, University of Ulm

Postdoctoral, University of Wisconsin, Madison

73
Publications

Selected Publications

Abortive infection of bat fibroblasts with SARS-CoV-2. Punam Bisht, Michael D. Gallagher, M. Inmaculada Barrasa, Julie Boucau, Alfred Harding, Marion Déjosez, Carlos Godoy-Parejo, Margaret E. Bisher, Giovanni de Nola, Abigail K.R. Lytton-Jean, Lee Gehrke, Thomas P. Zwaka, Rudolf Jaenisch. Proceedings of the National Academy of Sciences of the United States of America

Advancing stem cell technologies for conservation of wildlife biodiversity. Ashlee M. Hutchinson, Ruth Appeltant, Tom Burdon, Qiuye Bao, Rhishikesh Bargaje, Andrea Bodnar, Stuart Chambers, Pierre Comizzoli, Laura Cook, Yoshinori Endo, Bob Harman, Katsuhiko Hayashi, Thomas Hildebrandt, Marisa L. Korody, Uma Lakshmipathy, Jeanne F. Loring, Clara Munger, Alex H.M. Ng, Ben Novak, Manabu Onuma, Sara Ord, Monique Paris, Andrew J. Pask, Francisco Pelegri, Martin Pera, Ryan Phelan, Benyamin Rosental, Oliver A. Ryder, Woranop Sukparangsi, Gareth Sullivan, Nicole Liling Tay, Nikki Traylor-Knowles, Shawn Walker, Antonia Weberling, Deanne J. Whitworth, Suzannah A. Williams, Jessye Wojtusik, Jun Wu, Qi Long Ying, Thomas P. Zwaka, Timo N. Kohler. Development (Cambridge)

Generation of human pluripotent stem cell lines (WAe009-A) with THAP11<sub>F80L</sub> cobalamin disorder-associated mutation. Yiren Qin, Carlos Godoy-Parejo, Marta Skowronska, Angela Verma, Marion Dejosez, Thomas P. Zwaka. Stem Cell Research

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Zwaka during 2023 and/or 2024. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Founder/Co-Founder/Partner

  • Paratus Sciences

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.