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Talia H Swartz, MD, PhD
img_Talia H Swartz
SENIOR ASSOCIATE DEAN FOR MD/PHD EDUCATION
ASSOCIATE PROFESSOR | Medicine, Infectious Diseases
ASSOCIATE PROFESSOR | Medical Education
ASSOCIATE PROFESSOR | Artificial Intelligence and Human Health
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Specialties
Infectious Disease
Research Topics
Cellular Immunity, Cytokines, HIV/AIDS, Imaging, Immunology, Infectious Disease, Inflammation, Membrane Proteins/Channels, Membranes, Microbiology, Microglia, Mucosal Immunology, Opioid/Cannabinoid Receptors, T Cells, Translational Research, Transporters, Virulence Genes, Viruses and Virology
Multi-Disciplinary Training Area
Disease Mechanisms and Therapeutics (DMT), Genetics and Genomic Sciences [GGS], Immunology [IMM], Microbiology [MIC], Neuroscience [NEU]
Dissecting the mechanisms of HIV-1 infection and inflammatory signaling in human lymphoid tissue
Purinergic receptors and downstream inflammasome signaling mediators are important contributors to HIV-1 entry and in driving inflammation. Preliminary data indicate that inhibitors of purinergic signaling reduce both HIV-1 infection and inflammatory cytokine signaling. Our goal is to elucidate the role of HIV-1 in mediating inflammatory signaling in lymphoid tissue.
Functional Assessment of anti-Env and inflammatory markers during delayed FTR-mediated virologic control
The goal of this study is to test the role of enhanced antibody responses in the delayed virologic control observed in Fostemsavir treated patients who have multidrug resistant HIV.
Elucidating the mechanisms of cannabinoids on HIV-1 infection and inflammasome activation
Recent evidence has suggested an important role of the NLRP3 inflammasome as a driver of inflammation. Cannabinoids have been shown to reduce inflammasome activity. What remains unknown is the effect that cannabinoids have on HIV-stimulated NLRP3 inflammasome activity. Our goal is to elucidate the role of cannabinoids in modulating HIV-inflammasome signaling in lymphoid tissue.
Building a diverse and robust physician scientist pipeline
The lack of diversity in gender, race/ethnicity, of the physician scientist pipeline threatens the ability of the biomedical workforce to serve the needs of our patients. There is a critical need for us to expand the diversity of the physician scientist workforce through recruitment, admissions, and retention efforts.
Modeling HIV microglia-association infection and inflammation in a chimeric mouse brain
To better understand how HIV affects the brain in the era of combination antiretroviral therapy, and to improve current treatment options, we will study the cell susceptible to HIV infection human microglia, in the mouse brain. This includes novel experimental therapies of antiretrovirals combined with cannabinoid receptor-specific drugs that could lower the extent of inflammation and infection in the brain.

PhD, Mount Sinai School of Medicine

MD, Icahn School of Medicine at Mount Sinai

Residency, Internal Medicine, Mount Sinai Hospital

Fellowship, Infectious Disease, Mount Sinai Hospital

Certifications

American Board of Internal Medicine

2024

The Terry Ann Krulwich Physician-Scientist Alumni Award

Mount Sinai Alumni Association

2023

Women in Science (WiS) group and the Postdoc Executive Committee (PEC) Recognition Award

Icahn School of Medicine at Mount Sinai

2023

Co-Chair

AAMC Group on Research, Education, and Training (GREAT)

2023

Chair

AAMC Group on Research, Education, and Training (GREAT) MD-PhD Section

2023

Oswald Avery Award

Infectious Diseases Society of America

2022

Executive Committee Member

National Association of MD-PhD Programs

2021

Junior Faculty Research Award

Infectious Diseases Society of New York

2021

Fellow

Infectious Diseases Society of America

2020

Master Educator

Institute for Medical Education, Icahn School of Medicine at Mount Sinai

2020

Distinguished Scholar Award

Icahn School of Medicine at Mount Sinai

2019

Excellence in Teaching Award

Institute for Medical Education, Icahn School of Medicine at Mount Sinai

2018

Edward J. Ronan Award

Student Council, Icahn School of Medicine at Mount Sinai

2017

Translational Collaborative Research Development Award

Department of Medicine, Icahn School of Medicine at Mount Sinai

2016

Junior Faculty Award

Faculty Council, Icahn School of Medicine at Mount Sinai

2013

Alpha Omega Alpha Postgraduate Research Award

Lambda Chapter

2011

Alpha Omega Alpha, Resident/Fellow Member

Lambda Chapter

2010

House Staff Excellence in Teaching Award

Institute for Medical Education, Mount Sinai School of Medicine

63
Publications

Selected Publications

Shaping the Future of Infectious Diseases: The Journey to Promote Value, Opportunity, and Positive Messaging. Molly L. Paras, Lisa M. Chirch, Mariam Aziz, Gayle P. Balba, Constance Benson, Saira Butt, Scott H. James, Todd P. McCarty, Raymund Razonable, Rebecca Reece, Rachel Shnekendorf, Talia H. Swartz, J. Alex Viehman, Vera P. Luther. Open Forum Infectious Diseases

Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation. Nadine Schrode, Trinisia Fortune, Aislinn M. Keane, Jesse F. Mangold, Benjamin Tweel, Kristin G. Beaumont, Talia H. Swartz. Viruses

Reply to Barajas-Ochoa: The Imperative to Integrate International Medical Graduates into the Infectious Diseases Physician-Scientist Pathway: Expanding Opportunities and Overcoming Barriers. Talia H. Swartz, Senu Apewokin, Stephen M. Carpenter, Rana Chakraborty, Ann M. Dennis, Eric Houpt, Neeraj K. Surana, Danielle M. Zerr, Liise Anne Pirofski. Journal of Infectious Diseases

View All Publications

Talia Swartz HIV Education Video
HIV-Driven Inflammation: Insights from Single-Cell Analysis of Human Lymphoid Tissue
2020 Distinguished Scholar Award - Dr. Talia Swartz
Understanding the mechanisms of HIV-1 as an inflammatory disease
50th Anniversary: Dr. Talia Swartz Story
Mount Sinai Spotlight: HIV Research
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Annenberg Building Floor 23 Room 02A

1468 Madison Ave

New York, NY 10029

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Swartz has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.