Stuart C Sealfon, MD
img_Stuart C Sealfon
PROFESSOR | Neurology
PROFESSOR | Neuroscience
PROFESSOR | Pharmacological Sciences
Research Topics
Addiction, Apoptosis/Cell Death, Basal Ganglia, Bioinformatics, Brain, Cellular Immunity, Cerebral Cortex, Mathematical and Computational Biology, Multiple Sclerosis, Neuro-degeneration/protection, Receptors, Reproductive Biology, Signal Transduction, Theoretical Biology, Vaccine Development, Viruses and Virology
Multi-Disciplinary Training Area
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]

Specific Clinical/Research Interest: Systems biology of cellular signaling specificity in response to drugs or viruses

Current Students: Tony Yuen, Rosalind Ang, Soon-Gang Choi, David Braun

Postdoctoral Fellows: Jeremy Seto, Boris Hartmann, Joanna Gonzalez, Robert Bowles, Liang Qiao, Laura Abizu

Research Personnel: Science Admin: Lidija Ivic, Bioinformatics: Hanna Pincus, Computer Systems: German Nudelman, Techs: Ke Jiang, Esther Rhee, Ming Chen

Associated Faculty: Fernand Hayot, Robert Pfeffer, YongChao Ge Istvan Sugar

Summary of Research Studies:
We use high throughput experiments and modeling to study signaling systems that are important for understanding cellular responses relevant to Parkinson's disease, drug abuse, viral infection and neuroendocrine reproductive function. We are interested in elucidating the molecular mechanisms underlying receptor activation and coupling to signal transduction and in placing these events in a cellular and neurobiological context. The ultimate neurobehavioral effects of an agonist evolve from the specific molecular events that accompany the interaction with its receptor and the pattern of signal transduction that is elicited. How does a specific chemical stimulus lead to the resulting downstream cellular response? In order to address this deceptively simple question we have developed new approaches to study the mechanisms underlying signal coding and signaling specificity of G-protein coupled receptors and to study responses at the single cell level in complex systems. We are investigating these issues in several experimental systems.

1) Frequency-dependent Responses of the Gondotropin-Releasing Hormone Receptor. The GnRH-R is a key mediator of the reproductive neuroendocrine system and represents a key pharmaceutical target for neoplastic and reproductive disorders. The downstream gene responses obtained in the pituitary gonadotrope depend on the frequency of receptor activation. Using gene profiling technologies, we are probing the modulation of the signaling space induced by GnRH receptor activation and developing mathematical models to explain the basis for the frequency-dependence of the pattern of gene induction.

2) Receptor Determinants of Hallucinogen Effects. Hallucinogenic drugs of abuse, such as LSD, generate their psychotropic effects through their interaction with 5-HT2 subtype receptors and the serotonin-glutamate receptor complex we have recently identified.

3) Experiment-based modeling of dendritic cell responses to viruses: We are developing experimental-data based predictive mathematical models of dendritic cell responses to pathogenic viruses.

For more information, please visit the Sealfon Laboratory website.

MD, Columbia-Presbyterian Medical Center


''Identification of a serotonin/glutamate receptor complex implicated in psychosis'' rated ''Exceptional'' by Faculty of 1000, Biology, and ''Must Read'' by Faculty of 1000, Medicine

Faculty of 1000, Medicine


''BioPP: a tool for web-publication of biological networks'' rated ''Highly Accessed,'' BMC Bioinformatics


''Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice'' rated ''Recommended'' by Faculty of 1000, Biology


''Early single cell bifurcation of pro-and anti-apoptotic states during oxidative stress'' rated ''Must Read'' by Faculty of 1000, Biology


Physician-Scientist Award



Sciarra Prize in Neurology

Columbia University College of Physicians and Surgeons


Sandoz Award for Neuroscience Research

Columbia University College of Physicians and Surgeons


Alpha Omega Alpha

Columbia University


Phi Beta Kappa

Princeton University


Selected Publications

Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data. Xi Chen, Yuan Wang, Antonio Cappuccio, Wan Sze Cheng, Frederique Ruf Zamojski, Venugopalan D. Nair, Clare M. Miller, Aliza B. Rubenstein, German Nudelman, Alicja Tadych, Chandra L. Theesfeld, Alexandria Vornholt, Mary Catherine George, Felicia Ruffin, Michael Dagher, Daniel G. Chawla, Alessandra Soares-Schanoski, Rachel R. Spurbeck, Lishomwa C. Ndhlovu, Robert Sebra, Steven H. Kleinstein, Andrew G. Letizia, Irene Ramos, Vance G. Fowler, Christopher W. Woods, Elena Zaslavsky, Olga G. Troyanskaya, Stuart C. Sealfon. Nature Computational Science

Activating Transcription Factor 3 Stimulates Follicle-Stimulating Hormone-β Expression in Vitro but Is Dispensable for Follicle-Stimulating Hormone Production in Murine Gonadotropes in Vivo. Carlos A.I. Alonso, Caroline D. David, Chirine Toufaily, Ying Wang, Xiang Zhou, Luisina Ongaro, German Nudelman, Venugopalan D. Nair, Frederique Ruf-Zamojski, Ulrich Boehm, Stuart C. Sealfon, Daniel J. Bernard. Endocrinology

Blood RNA alternative splicing events as diagnostic biomarkers for infectious disease. Zijun Zhang, Natalie Sauerwald, Antonio Cappuccio, Irene Ramos, Venugopalan D. Nair, German Nudelman, Elena Zaslavsky, Yongchao Ge, Angelo Gaitas, Hui Ren, Joel Brockman, Jennifer Geis, Naveen Ramalingam, David King, Micah T. McClain, Christopher W. Woods, Ricardo Henao, Thomas W. Burke, Ephraim L. Tsalik, Carl W. Goforth, Rhonda A. Lizewski, Stephen E. Lizewski, Dawn L. Weir, Andrew G. Letizia, Stuart C. Sealfon, Olga G. Troyanskaya. Cell Reports Methods

View All Publications

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Sealfon during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Company Founder:

  • GNOMX Corp.

Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)

  • Innovative Health Science

Royalty Payments:

  • Astellas Pharma Inc.
  • Millipore
  • Neurocrine Biosciences, Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.