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Sergio Lira, MD, PhD
img_Sergio Lira
PROFESSOR | Immunology & Immunotherapy
PROFESSOR | Medicine, Clinical Immunology
212-659-9404
email
Research Topics
Autoimmunity, Cancer, Cell Motility, Cellular Immunity, Chemokines, Chemotaxis, Imaging, Immunology, Inflammation, Inflammatory Bowel Disease (IBD), Knockout Mice, Mucosal Immunology, Oncogenes, Organogenesis, Pathology, T Cells, Tolerance, Trafficking, Transgenic Mice, Tumorigenesis, Viruses and Virology
Multi-Disciplinary Training Area
Cancer Biology [CAB], Immunology [IMM]
Technologies
  • Engineering mouse mutants using  the CRISPR/Cas technology
  • Single cell transcriptomics
  • Imaging
  • Intestinal organoids

    • Research

    Specific Clinical/Research Interest: Mucosal Immunology; Microbiota; Cancer; Inflammation; Chemokines; Leukocyte trafficking; Lymphoid Development; Mouse genetics; IL-23 biology

    Co-PI: Glaucia Furtado, PhD. Associate Professor

    Postdoctoral Fellows: Lili Chen, Zhengziang He, Grace Chen

    Visiting Scientist: Valentina Strohmeier (U. Freiburg, Germany)


    Summary of Research Studies:
    We use genetic approaches in mice to study the function of cytokines and their receptors in mucosal immunology, inflammation and cancer. Recent work in the laboratory focuses:

    1) role of microbiome in inflammation in cancer.

    2) impact of environmental factors such as diet in inflammation and autoimmunity

    3) neonatal inflammation

    For more information, please visit the Lira Lab page http://labs.icahn.mssm.edu/liralab/our-research-2/

    Post-doctoral, Roche Institute of Molecular Biology

    MD, U. Federal de Pernambuco

    PhD, University of California

    216
    Publications

    Selected Publications

    Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection. Xiaomin Yao, Eugene Rudensky, Patricia K. Martin, Brittany M. Miller, Isabel Vargas, Erin E. Zwack, Keenan A. Lacey, Zhengxiang He, Glaucia C. Furtado, Sérgio A. Lira, Victor J. Torres, Bo Shopsin, Ken Cadwell. Immunity

    Revealing New Prospects: Antipsychotic Drugs Induces Anti-tumor Effects against Gastric Cancer through Inducing Apoptosis. Omolbanin Amjadi, Akbar Hedayatizadeh-Omran, Ehsan Zaboli, Ghasem Janbabaei, Sergio A. Lira, Ghasem Ahangari. Current Cancer Drug Targets

    Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease. Michelle Khrom, Millie Long, Shishir Dube, Lori Robbins, Gregory J. Botwin, Shaohong Yang, Emebet Mengesha, Dalin Li, Takeo Naito, Nirupama N. Bonthala, Christina Ha, Gil Melmed, Shervin Rabizadeh, Gaurav Syal, Eric Vasiliauskas, David Ziring, Steven R. Brant, Judy Cho, Richard H. Duerr, John Rioux, Phil Schumm, Mark Silverberg, Ashwin N. Ananthakrishnan, William A. Faubion, Bana Jabri, Sergio A. Lira, Rodney D. Newberry, Robert S. Sandler, Ramnik J. Xavier, Subra Kugathasan, David Hercules, Stephan R. Targan, R. Balfour Sartor, Talin Haritunians, Dermot P.B. McGovern. Gastroenterology

    View All Publications

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    212-659-9404

    Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

    Below are financial relationships with industry reported by Dr. Lira during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

    Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.