Scott L Friedman, MD
img_Scott L Friedman
PROFESSOR | Medicine, Liver Diseases
PROFESSOR | Pharmacological Sciences
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Internal Medicine, Gastroenterology
Research Topics
Aerodigestive Tract, Anti-Tumor Therapy, Apoptosis/Cell Death, Autophagy, Biomedical Sciences, Cancer Genetics, Cell Biology, Cell Transformation, Developmental Biology, Drug Resistance, Endothelial Cells, Epithelial Cells, Extracellular Matrix, Fibrosis, Gene Regulation, Growth Factors and Receptors, Hepatitis C Virus, Integrins, Knockout Mice, Liver, Macrophage, Metastasis, Molecular Biology, Organogenesis, Oxidative Stress, Phosphorylation, Proteases, Receptors, Signal Transduction, Transcription Factors, Transcriptional Activation and Repression, Transgenic Mice, Tumor Suppressor Genes, Tumorigenesis, Vascular Development, Wound Healing
Multi-Disciplinary Training Area
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)
Mechanisms of Hepatic Fibrosis and Cancer
Dr. Friedman is the Director of both the Division of Liver Diseaases and the Fibrosis Research Center, and is co-Director of the Tisch Cancer Institute Liver Cancer Program

Specific Clinical/Research Interest:
  • Cellular and molecular mechanisms of hepatic fibrosis and cancer
  • Diagnosis and development of anti-fibrotic therapies for patients with chronic liver disease
  • Clinical trials of antifibrotic therapies in patients with chronic liver disease

Current Students: Billie Bian PhD Student, Fatemah Parvin-Nejad, MD Student; Benjamin Wooden, MD Student

Current Postdoctoral Fellows: Youngjoon Yoon, MD; Takuma Tsuchida PhD;

Research Personnel: Hsin Chou, M.S. (Lab Manager); Dipankar Bhattacharya, M.S.

Summary of Research Studies:

Our work explores the molecular mechanisms of wound healing and fibrosis in liver and how they contribute to liver cancer. We use a variety of animal and cell culture models to identify key inflammatory mediatiors and signaling molecules regulating the activation of hepatic stellate cells, the principle fibrogenic cells in liver. Additionally, we test candidate antifibrotic lead compounds to develop potential new therapies for patients with chronic fibrosing liver diseases. Specific projects include:

- Molecular mechanisms of hepatic stellate cell activation and the cell's role iin hepatic regeneration, immunity and repair
-Testing of antifibrotic lead compounds in animal models
-Clinical trials of antifibrotic therapies in patients with chronic liver disease

BS, Rensselaer Polytechnic Institute

MD, Icahn School of Medicine at Mount Sinai

Residency, Internal Medicine, Beth Israel Deaconess Medical Center-Main Campus

Residency, Internal Medicine, Beth Israel Deaconess Medical Center-Main Campus

Fellowship, Gastroenterology, University of CA at San Francisco Medical Center


American Board of Internal Medicine


Am Assn for the Study of Liver Diseases Distinguished Achievement Award



American Liver Foundation Distinguished Achievement Award

American Liver Foundation


Emmet B Keeffe Mentoring Award

Recognizes outstanding mentorship in the field of hepatology


Fellow, American Assn for the Advancement fo Science



Maud Menten Honorary Lecture

U. Pittsburgh


Burton Combes Memorial Lecture

UT Southwestern GI Division


Charles Lieber Memorial Lecture

American Gastroenterological Assn


China Friendship Award

Chinese Government, presented by the Premier of China


The Jacobi Medallion

The Icahn School of Medicine at Mount Sinai


Salute to Excellence Award

American Liver Foundation, San Francisco Chapter



Am Assn for the Study of Liver Diseases



American Assn for the Study of Liver Diseases


Rao Honorary Lecture

Feinberg School of Medicine, Northwestern U.


International Recognition Award

European Assn for the Study of LIver


Shanghai Magnolia Gold Award

City of Shanghai


Master Educator Recognition

Mount Sinai Institute for Medical Education


Englert Lecture

University of Utah Dept of Medicine


Rafael Research Alumni Visiting Scientist

Rambam Hospital, Haifa, Israel


Sheila Sherlock Lecture

British Assn for Gastroenterology, Liverpool, UK


Sackler Distinguished Lectureship

Tel Aviv University, Israel


Fellow of the American Gastroenterological Assn


Ken & Louise Goldberg Visiting Professor

Brigham and Women's Hospital, Boston MA


Solomon Berson Dept of Medicine Housestaff Teaching Award


International Hans Popper Research Prize

Falk foundation


International Hans Popper Award to Outstanding Researcher in Hepatology


Fulbright Senior Scholar Award


Arthur H. Aufses Sr., Prize in Surgery

Mount Sinai School of Medicine


Selected Publications

Swept up in the tsunami: Pediatric and adolescent steatotic (fatty) liver disease. Scott L. Friedman. Med

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD). Michele Vacca, Ioannis Kamzolas, Lea Mørch Harder, Fiona Oakley, Christian Trautwein, Maximilian Hatting, Trenton Ross, Barbara Bernardo, Anouk Oldenburger, Sara Toftegaard Hjuler, Iwona Ksiazek, Daniel Lindén, Detlef Schuppan, Sergio Rodriguez-Cuenca, Maria Manuela Tonini, Tamara R. Castañeda, Aimo Kannt, Cecília M.P. Rodrigues, Simon Cockell, Olivier Govaere, Ann K. Daly, Michael Allison, Kristian Honnens de Lichtenberg, Yong Ook Kim, Anna Lindblom, Stephanie Oldham, Anne Christine Andréasson, Franklin Schlerman, Jonathon Marioneaux, Arun Sanyal, Marta B. Afonso, Ramy Younes, Yuichiro Amano, Scott L. Friedman, Shuang Wang, Dipankar Bhattacharya, Eric Simon, Valérie Paradis, Alastair Burt, Ioanna Maria Grypari, Susan Davies, Ann Driessen, Hiroaki Yashiro, Susanne Pors, Maja Worm Andersen, Michael Feigh, Carla Yunis, Pierre Bedossa, Michelle Stewart, Prodromos Hytiroglou. Nature Metabolism

Consequences of Amyloid-β Deficiency for the Liver. Gayane Hrachia Buniatian, Ute Schwinghammer, Roman Tremmel, Holger Cynis, Thomas S. Weiss, Ralf Weiskirchen, Volker M. Lauschke, Sonia Youhanna, Isbaal Ramos, Maria Valcarcel, Torgom Seferyan, Jens Ulrich Rahfeld, Vera Rieckmann, Kathrin Klein, Marine Buadze, Victoria Weber, Valentina Kolak, Rolf Gebhardt, Scott L. Friedman, Ulrike C. Müller, Matthias Schwab, Lusine Danielyan. Advanced Science

View All Publications

The Dawn of Translation in NASH and Hepatic Fibrosis
Drug, Diagnostic and Device Development: From Scientific Findings to FDA Approval
Scott Friedman, MD

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Friedman during 2023 and/or 2024. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

  • Boston Pharmaceuticals
  • Mediar Therapeutics
  • AGED Diagnostics
  • Takeda Pharmaceuticals Of North America, Inc.
  • InSitro
  • Pfizer Pharmaceuticals
  • HepGene
  • Ochre Bio
  • RAPT Therapeutics, Inc.
  • Junevity
  • Merck & Co., Inc.
  • 89bio Inc
  • Boehringer Ingelheim, Ltd.
  • Laekna
  • Macomics
  • Kriya
  • Satellite Bio
  • Scholar Rock
  • Morphic Therapeutic
  • Gordian Biotechnology
  • Surrozen
  • Acceler, Korea
  • Variant BIo
  • AgoMab
  • Carisma Therapeutics
  • Overtone Therapeutics
  • Sagimet Biosciences
  • Therasid Bio
  • Korro BIo
  • Wrench Bio
  • Resolution Therapeutics
  • Incendia Therapeutics
  • North Sea Therapeutics

Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)

  • Mediar Therapeutics
  • Satellite Bio
  • AGED Diagnostics
  • Scholar Rock
  • InSitro
  • Morphic Therapeutic
  • Gordian Biotechnology
  • Surrozen
  • HepGene
  • Ochre Bio
  • Junevity
  • Sagimet Biosciences
  • Laekna
  • North Sea Therapeutics

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.