Saghi Ghaffari, MD, PhD
img_Saghi Ghaffari
PROFESSOR | Cell, Developmental & Regenerative Biology
PROFESSOR | Oncological Sciences
Research Topics
Blood, Cancer, Cell Transformation, Hematopoiesis, Leukemia, Metabolism, Oxidative Stress, Stem Cells
Multi-Disciplinary Training Area
Cancer Biology [CAB], Development Regeneration and Stem Cells [DRS]
Blood, Blood Disorders and Stem Cells
The Ghaffari lab works on exposing mechanisms that maintain healthy blood stem and progenitor cell production throughout life that may be perturbed in blood disorders. The lab explores these mechanisms to ultimately improve blood production for therapy including bone marrow transplantation and to interfere with disease. The topics of interest in the laboratory are blood forming (hematopoietic) stem cells, their alterations with aging and in myeloid malignancies as well as maturation of red blood cells and their alterations in disease. We are particularly focused on metabolic programs regulated through organelles outside of the nucleus that impact blood production. This approach has been fruitful in identifying new players that are promising in their potential impact on bone marrow transplantation. In carrying our work forward, we have set up multiple collaborations with investigators at Mount Sinai and elsewhere. Several projects derived from our work are available to PhD and MD/PhD students at Mount Sinai.

MD, Universite de Paris XII, Paris, France

Clinical Scientist, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology

MSc, Universite de Paris XII, Paris, France

PhD, University of British Columbia, Vancouver, B.C., Canada


American Society of Hematology Bridge Grant Award

American Society of Hematology


Myeloproliferative Neoplam (MPN) Foundation

Research Foundation New Investigator Award


Roche Foundation for Anemia Research (RoFAR) Award


Irma Hirschl/Weill-Caulier Trust Research Award


NIH Clinician Scientist Career Award

National Cancer Institute


American Cancer Society Research Scholar

American Cancer Society


Terry Fox Physician-Scientist Fellowship National Cancer Institute of Canada

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Ghaffari did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.