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Sacha Gnjatic, PhD
img_Sacha Gnjatic
PROFESSOR | Immunology & Immunotherapy
PROFESSOR | Oncological Sciences
PROFESSOR | Pathology, Molecular and Cell Based Medicine
PROFESSOR | Medicine, Hematology and Medical Oncology
email
Research Topics
Anti-Tumor Therapy, Antigen Presentation, B Cells, Cancer, Cellular Immunity, Dendritic Cells, Immunological Tolerance, Immunology, Immunosuppression, Lung, Microarray, Proteomics, T Cells, Tolerance, Translation, Vaccine Development
Multi-Disciplinary Training Area
Disease Mechanisms and Therapeutics (DMT), Immunology [IMM]
Mechanisms of antigen presentation to T cells:
Mechanisms of antigen presentation to and recognition by T cells, including defining epitopes, evaluating viral, bacterial, and parasitic vectors, cross-presentation of antigen to HLA class I, and endogenous antigen presentation to HLA class II.
Tissue immune microenvironment:
Assessment of the tumor microenvironment for immunocytes and suppressive signals, including development of novel spatial technologies to address in depth biomarkers at the tissue site.
Impact of immunoregulation on tumor antigen-specific responses:
Impact of immunoregulation on tumor antigen-specific responses, from co-inhibitory molecules expressed on T cells at the tumor site to the effect of regulatory T cells on anti-tumor effectors, and study of immune tolerance.
Inflammatory diseases:
Role of GM-CSF autoantibodies throughout Crohn's disease development. Dissecting role of cytokines, antibody and T cell responses in COVID-19 patients after infection or vaccination.
Immune monitoring to discover mechanisms and biomarker of cancer immunotherapies:
Multiscale (host, circulation, tissues, single cell), multiomics (immunophenotyping, immunopathology, immunotranscriptomics, bioinformatics) approaches for biomarker discovery and understanding of mechanisms contributing to clinical responses, adverse events, or primary and acquired resistance to tumor immunotherapies.
Antigen-specific spontaneous and immunotherapy-induced tumor immunity:
Characterization of serological and cellular immune responses against tumor antigens such as NY-ESO-1, MAGE-A3, or p53, and for their capacity to induce immune responses both spontaneously and in the setting of cancer immunotherapy.

BSc3, University College London

MSc, Institut Pasteur

Undergraduate, Ecole Normale Supérieure

PhD, University Paris VII

Post-doc, Memorial Sloan-Kettering - Ludwig Institute

262
Publications

Selected Publications

Phase II basket trial of Dual AntiCTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) SWOG S1609: pancreatic neuroendocrine neoplasm (PNEN) cohort. Sandip Pravin Patel, Jillian Fisher, Young Kwang Chae, Luisa Solis Soto, Anup Kasi, Bhavana Konda, Mark Walshauser, Edwin Parra, Jiexin Zhang, Caroline Duault, Edgar Gonzalez-Kozlova, Ganiraju Manyam, Jianhua Zhang, Hong Chen, Dzifa Yawa Duose, Caddie Laberiano Fernandez, Raja Luthra, Gheath Al-Atrash, Seunghee Kim-Schulze, Holden T. Maecker, Ignacio I. Wistuba, Sacha Gnjatic, J. Jack Lee, Jianjun Zhang, Christine M. Magner, Helen X. Chen, Elad Sharon, Megan Othus, Christopher W. Ryan, Charles Blanke, Cara L. Haymaker, Razelle Kurzrock. Journal for ImmunoTherapy of Cancer

The Society for Immunotherapy of Cancer Perspective on Liquid Biopsy– and Radiomics-Based Technologies for Immuno-oncology Biomarker Discovery and Application. Anne Monette, Adriana Aguilar-Mahecha, Emre Altinmakas, Mathew G. Angelos, Nima Assad, Gerald Batist, Praveen K. Bommareddy, Diana L. Bonilla, Christoph H. Borchers, Sarah E. Church, Gennaro Ciliberto, Alexandria P. Cogdill, Luigi Fattore, Nir Hacohen, Mohammad Haris, Vincent Lacasse, Wen Rong Lie, Arnav Mehta, Marco Ruella, Sam Sater, Alan Spatz, Bachir Taouli, Imad Tarhoni, Edgar Gonzalez-Kozlova, Itay Tirosh, Xiaodong Wang, Sacha Gnjatic. Clinical Cancer Research

Peripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV-2 Infection. Pushkala Jayaraman, Madhumitha Rajagopal, Ishan Paranjpe, Mayte Suarez-Farinas, Lora E. Liharska, Ryan C. Thompson, Diane Marie Del Valle, Noam D. Beckmann, Anina N. Lund, Pooja Gownivaripally, Wonsuk Oh, Faris F. Gulamali, Justin Kauffman, Edgar Gonzalez-Kozlova, Sergio Dellepiane, George Vasquez-Rios, Akhil Vaid, Joy Jiang, Ben Fox, Ankit Sakhuja, Steven Chen, Ephraim Kenigsberg, John Cijiang He, Steven G. Coca, Lili Chan, Miram Merad, Seunghee Kim-Schulze, Sacha Gnjatic, Ephraim L. Tsalik, Raymond Langley, Alexander W. Charney, Girish N. Nadkarni. Kidney360

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Gnjatic during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

  • Taiho Oncology, Inc
  • Memorial Sloan-Kettering Cancer Center
  • National Cancer Institute/NIH/DHHS
  • Society for Immunotherapy of Cancer

Editorial Services

  • Cancer Immunology Research
  • Frontiers in Immunology

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.