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Sacha Gnjatic, PhD
img_Sacha Gnjatic
PROFESSOR | Immunology & Immunotherapy
PROFESSOR | Medicine, Hematology and Medical Oncology
PROFESSOR | Pathology, Molecular and Cell Based Medicine
PROFESSOR | Oncological Sciences
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Research Topics
Anti-Tumor Therapy, Antigen Presentation, B Cells, Cancer, Cellular Immunity, Dendritic Cells, Immunological Tolerance, Immunology, Immunosuppression, Lung, Microarray, Proteomics, T Cells, Tolerance, Translation, Vaccine Development
Multi-Disciplinary Training Area
Disease Mechanisms and Therapeutics (DMT), Immunology [IMM]
Mechanisms of antigen presentation to T cells:
Mechanisms of antigen presentation to and recognition by T cells, including defining epitopes, evaluating viral, bacterial, and parasitic vectors, cross-presentation of antigen to HLA class I, and endogenous antigen presentation to HLA class II.
Inflammatory diseases:
Role of GM-CSF autoantibodies throughout Crohn's disease development. Dissecting role of cytokines, antibody and T cell responses in COVID-19 patients after infection or vaccination.
Immune monitoring to discover mechanisms and biomarker of cancer immunotherapies:
Multiscale (host, circulation, tissues, single cell), multiomics (immunophenotyping, immunopathology, immunotranscriptomics, bioinformatics) approaches for biomarker discovery and understanding of mechanisms contributing to clinical responses, adverse events, or primary and acquired resistance to tumor immunotherapies.
Antigen-specific spontaneous and immunotherapy-induced tumor immunity:
Characterization of serological and cellular immune responses against tumor antigens such as NY-ESO-1, MAGE-A3, or p53, and for their capacity to induce immune responses both spontaneously and in the setting of cancer immunotherapy.
Tissue immune microenvironment:
Assessment of the tumor microenvironment for immunocytes and suppressive signals, including development of novel spatial technologies to address in depth biomarkers at the tissue site.
Impact of immunoregulation on tumor antigen-specific responses:
Impact of immunoregulation on tumor antigen-specific responses, from co-inhibitory molecules expressed on T cells at the tumor site to the effect of regulatory T cells on anti-tumor effectors, and study of immune tolerance.

BSc3, University College London

MSc, Institut Pasteur

Undergraduate, Ecole Normale Supérieure

PhD, University Paris VII

Post-doc, Memorial Sloan-Kettering - Ludwig Institute

271
Publications

Selected Publications

Could a COVID-19 vaccine improve the effectiveness of cancer immunotherapy?. Sacha Gnjatic. Nature Reviews Clinical Oncology

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma. William C. Pilcher, Lijun Yao, Edgar Gonzalez-Kozlova, Yered Pita-Juarez, Dimitra Karagkouni, Chaitanya R. Acharya, Marina E. Michaud, Mark Hamilton, Shivani Nanda, Yizhe Song, Kazuhito Sato, Julia T. Wang, Sarthak Satpathy, Yuling Ma, Jessica Schulman, Darwin D’Souza, Reyka G. Jayasinghe, Denis Ohlstrom, Katherine E. Ferguson, Giulia Cheloni, Mojtaba Bakhtiari, Nick Pabustan, Kai Nie, Jennifer A. Foltz, Isabella Saldarriaga, Rania Alaaeldin, Eva Lepisto, Rachel Chen, Mark A. Fiala, Beena E. Thomas, April Cook, Junia Vieira Dos Santos, Chiang I-ling, Igor Figueiredo, Julie Fortier, Michael Slade, Stephen T. Oh, Michael P. Rettig, Emilie Anderson, Ying Li, Nicolas F. Fernandez, Geoffrey Kelly, Brian H. Lee, Travis Dawson, Adeeb H. Rahman, Zhihong Chen, Alessandro Lagana, Seunghee Kim-Schulze, Hearn J. Cho, Sacha Gnjatic. Nature Cancer

Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade. Edgar Gonzalez-Kozlova, Robert Sweeney, Igor Figueiredo, Kevin Tuballes, Sinem Ozbey, Pauline Hamon, Matthew D. Park, Giorgio Ioannou, Yohei Nose, Ruiwei Guo, Paula Restrepo, Mark Buckup, Vladimir Roudko, Clotilde Hennequin, Jessica Le Berichel, Nicholas Venturini, Laszlo Halasz, Leanna Troncoso, Alexandra Tabachnikova, Christie Chang, Amanda Reid, Haley Brown, Theodore Chin, Rafael Cabal, Raphaël Mattiuz, Shingo Eikawa, Diane Marie Del Valle, Tina Ruth Gonsalves, Nelson M. LaMarche, Hajra Jamal, Alona Lansky, Nancy Yi, Daniella Nelson, Jarod Morgenroth-Rebin, Raphael Merand, Bryan Villagomez, Darwin D’Souza, Emir Radkevich, Kai Nie, Zhihong Chen, Yasuko Tada, Hiroyoshi Nishikawa, Stephen C. Ward, Maria Isabel Fiel, Rachel Brody, Parissa Tabrizian, Ganesh Gunasekaran, Alice O. Kamphorst, Noah Cohen, Maria Curotto de Lafaille, Olivia Hapanowicz, Natalie Lucas, Kathy Wu, Nicola James, John C. Lin, Gavin Thurston, Myron Schwartz, Nathalie Fiaschi, Seunghee Kim-Schulze, Miriam Merad, Thomas U. Marron, Sacha Gnjatic. Nature Medicine

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Gnjatic during 2025 and/or 2026. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

  • Taiho Oncology, Inc
  • Memorial Sloan-Kettering Cancer Center
  • National Cancer Institute/NIH/DHHS
  • Society for Immunotherapy of Cancer
  • Gilead Sciences

Editorial Services

  • Cancer Immunology Research
  • Frontiers in Immunology

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.