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Sacha Gnjatic, PhD

img_Sacha Gnjatic
PROFESSOR | Immunology & Immunotherapy
PROFESSOR | Pathology, Molecular and Cell Based Medicine
PROFESSOR | Oncological Sciences
PROFESSOR | Medicine, Hematology and Medical Oncology
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Research Topics
Anti-Tumor Therapy, Antigen Presentation, B Cells, Cancer, Cellular Immunity, Dendritic Cells, Immunological Tolerance, Immunology, Immunosuppression, Lung, Microarray, Proteomics, T Cells, Tolerance, Translation, Vaccine Development
Multi-Disciplinary Training Area
Disease Mechanisms and Therapeutics (DMT), Immunology [IMM]
Antigen-specific spontaneous and immunotherapy-induced tumor immunity:
Characterization of serological and cellular immune responses against tumor antigens such as NY-ESO-1, MAGE-A3, or p53, and for their capacity to induce immune responses both spontaneously and in the setting of cancer immunotherapy.
Inflammatory diseases:
Role of GM-CSF autoantibodies throughout Crohn's disease development. Dissecting role of cytokines, antibody and T cell responses in COVID-19 patients after infection or vaccination.
Immune monitoring to discover mechanisms and biomarker of cancer immunotherapies:
Multiscale (host, circulation, tissues, single cell), multiomics (immunophenotyping, immunopathology, immunotranscriptomics, bioinformatics) approaches for biomarker discovery and understanding of mechanisms contributing to clinical responses, adverse events, or primary and acquired resistance to tumor immunotherapies.
Mechanisms of antigen presentation to T cells:
Mechanisms of antigen presentation to and recognition by T cells, including defining epitopes, evaluating viral, bacterial, and parasitic vectors, cross-presentation of antigen to HLA class I, and endogenous antigen presentation to HLA class II.
Impact of immunoregulation on tumor antigen-specific responses:
Impact of immunoregulation on tumor antigen-specific responses, from co-inhibitory molecules expressed on T cells at the tumor site to the effect of regulatory T cells on anti-tumor effectors, and study of immune tolerance.
Tissue immune microenvironment:
Assessment of the tumor microenvironment for immunocytes and suppressive signals, including development of novel spatial technologies to address in depth biomarkers at the tissue site.

BSc3, University College London

MSc, Institut Pasteur

Undergraduate, Ecole Normale Supérieure

PhD, University Paris VII

Post-doc, Memorial Sloan-Kettering - Ludwig Institute

275
Publications

Selected Publications

CD3 and PD-L1 tissue expression have synergistic value in head and neck squamous cell carcinoma prognosis. Adrian v. Witzleben, Romain Remark, Christian Idel, Julika Ribbat-Idel, Rosemarie Krupar, Andreas Schröck, Niklas Klümper, Johannes Doescher, Andrew G. Sikora, Tsima Abou Kors, Julius M. Vahl, Matthias Brand, Michael Sonntag, Cornelia Brunner, Thomas K. Hoffmann, Sven Perner, Sacha Gnjatic, Simon Laban. Translational Oncology

Single-cell spatial transcriptomic analysis of human skin anatomy. Paula Restrepo, Alexis Wilder, Aubrey Houser, Harkirat Singh Sandhu, Angie Ramirez, M. Grace Hren, Raman Gill, Abiha Kazmi, Larry Chen, Alexandra Nigro, Ichiro Imanishi, Deniz Demircioglu, Dan Hasson, Alan Soto, Stephanie McQuillan, Edgar Gonzalez-Kozlova, Rachel Brody, Benjamin Ungar, Maria Kasper, Catherine P. Lu, Philip Torina, Jesse M. Lewin, Sacha Gnjatic, Sai Ma, Andrew L. Ji. Nature Genetics

Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma. Denis J. Ohlstrom, William C. Pilcher, Marina E. Michaud, Chaitanya Acharya, Sarthak Satpathy, Edgar Gonzalez-Kozlova, Reyka G. Jayasinghe, Katherine Ferguson, Hope L. Mumme, Shivani Nanda, Yizhe Song, Sowmitri Mantrala, Dimitra Karagkouni, Jessica Schulman, Nick Pabustan, Junia Vieira Dos Santos, Daniel W. Sherbenou, Jonathan J. Keats, Alexander M. Gout, Steven Foltz, Alessandro Lagana, Taxiarchis Kourelis, Ravi Vij, Madhav V. Dhodapkar, David Avigan, Hearn Jay Cho, Linda B. Baughn, Ajay K. Nooka, Sagar Lonial, Shaji Kumar, Mehmet K. Samur, Ioannis S. Vlachos, Li Ding, Sacha Gnjatic, George Mulligan, Manoj K. Bhasin. Blood cancer discovery

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Gnjatic during 2025 and/or 2026. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

  • Taiho Oncology, Inc
  • Memorial Sloan-Kettering Cancer Center
  • National Cancer Institute/NIH/DHHS
  • Society for Immunotherapy of Cancer
  • Gilead Sciences

Editorial Services

  • Cancer Immunology Research
  • Frontiers in Immunology

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.