Roger Clem, PhD
img_Roger Clem
PROFESSOR | Neuroscience
PROFESSOR | Psychiatry
Research Topics
Auditory, Behavior, Brain, Cerebral Cortex, Cognitive Neuroscience, Depression, Electrophysiology, Glutamate (NMDA & AMPA) Receptors, Growth Factors and Receptors, Hippocampus, Knockout Mice, Memory, Neural Networks, Neurophysiology, Synaptic Plasticity, Synaptogenesis, Systems Neuroscience
Multi-Disciplinary Training Area
Neuroscience [NEU]
Emotional Brain Plasticity

Clem Laboratory

Emotional memories mediate adaptive behavioral reactions to dangerous and rewarding situations. However, memories acquired during intense emotional experiences also contribute to debilitating conditions like post-traumatic stress disorder and addiction. One basis for these powerful effects is the association of stimuli that were encountered during trauma or drug use with the experience of threat or pleasure. Our laboratory aims to understand how such associations are stored in the brain, and identify circuit mechanisms by which they can be alleviated.

We utilize a combination of approaches including optogenetics, synaptic electrophysiology and calcium imaging, to identify how neural pathways and individual neurons are engaged and modified during memory storage. Once memories are established, other experiments address the mechanisms that contribute to their reinforcement or attenuation by molecular and behavioral interventions.

Research Personnel

Rasika Iyer -- Research Associate

Anthony Lacagnina, Ph.D. -- Postdoctoral Fellow

Tri Dong -- Ph.D. student

PhD, Carnegie Mellon University

Johns Hopkins University


Cook Research Partnership Award

Friedman Brain Institute


FBI Research Scholar Award

Friedman Brain Insitute


NARSAD Young Investigator Award


Finalist, Eppendorf and Science Prize for Neurobiology


Daniel Nathans Research Award

Johns Hopkins University


National Research Service Award


Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Clem has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.