Robert M Samstein, MD, PhD
img_Robert M Samstein
ASSISTANT PROFESSOR | Radiation Oncology
ASSISTANT PROFESSOR | Immunology & Immunotherapy
Are you a patient?
Specialties
Radiation Oncology
Research Topics
Anti-Tumor Therapy, Autoimmunity, Biomedical Sciences, Breast Cancer, Cancer, Cancer Genetics, Cellular Immunity, Clinical Genomics, DNA Recombination, DNA Repair, Genetics, Genomics, Immunology, Mucosal Immunology, Oncogenes, Personalized Medicine, Pharmacogenomics, T Cells, Translational Research, Tumor Suppressor Genes, Tumorigenesis
Multi-Disciplinary Training Area
Cancer Biology [CAB], Immunology [IMM]
Dr. Samstein’s research interests are focused on understanding the interaction between the patient’s immune system and cancer cells in the tumor, elucidating the role of the DNA damage repair and response pathway in altering the tumor’s ability to be recognized and attacked by the immune system. His laboratory will work to identify new strategies to harness the immune anti-tumor response and expand the therapeutic window of traditional immunotherapies.

Visit the Samstein Laboratory

MD, Weill Medical College of Cornell University

MD, Weill Cornell Medical College

PhD, Weill Cornell / Sloan Kettering / Rockefeller Tri-I MD-PhD Program

Memorial Sloan Kettering Cancer Center

Internship, Transitional Year, Memorial Sloan-Kettering Cancer Center

Residency, Radiation Oncology, Memorial Sloan-Kettering Cancer Center

Certifications

Radiation Oncology

2020

Solomon Silver Award in Clinical Medicine

2020

American Association of Immunologists Pfizer-Showell Award

2019

Burrough Wellcome Career Award for Medical Scientists

2019

RSNA Roentgen Reseach Award

2018

AACR Translational Immunology Award

2017

American Board of Radiology Holman Research Pathway

Publications

Selected Publications

Prediction of checkpoint inhibitor immunotherapy efficacy for cancer using routine blood tests and clinical data. Seong Keun Yoo, Conall W. Fitzgerald, Byuri Angela Cho, Bailey G. Fitzgerald, Catherine Han, Elizabeth S. Koh, Abhinav Pandey, Hannah Sfreddo, Fionnuala Crowley, Michelle Rudshteyn Korostin, Neha Debnath, Yan Leyfman, Cristina Valero, Mark Lee, Joris L. Vos, Andrew Sangho Lee, Karena Zhao, Stanley Lam, Ezekiel Olumuyide, Fengshen Kuo, Eric A. Wilson, Pauline Hamon, Clotilde Hennequin, Miriam Saffern, Lynda Vuong, A. Ari Hakimi, Brian Brown, Miriam Merad, Sacha Gnjatic, Nina Bhardwaj, Matthew D. Galsky, Eric E. Schadt, Robert M. Samstein, Thomas U. Marron, Mithat Gönen, Luc G.T. Morris, Diego Chowell. Nature Medicine

Author Correction: Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial(Nature Medicine, 10.1038/s41591-023-02568-1). Matthew D. Galsky, Siamak Daneshmand, Sudeh Izadmehr, Edgar Gonzalez-Kozlova, Kevin G. Chan, Sara Lewis, Bassam El Achkar, Tanya B. Dorff, Jeremy Paul Cetnar, Brock O. Neil, Anishka D’Souza, Ronac Mamtani, Christos Kyriakopoulos, Tomi Jun, Mahalya Gogerly-Moragoda, Rachel Brody, Hui Xie, Kai Nie, Geoffrey Kelly, Amir Horowitz, Yayoi Kinoshita, Ethan Ellis, Yohei Nose, Giorgio Ioannou, Rafael Cabal, Diane M. Del Valle, G. Kenneth Haines, Li Wang, Kent W. Mouw, Robert M. Samstein, Reza Mehrazin, Nina Bhardwaj, Menggang Yu, Qianqian Zhao, Seunghee Kim-Schulze, Robert Sebra, Jun Zhu, Sacha Gnjatic, John Sfakianos, Sumanta K. Pal. Nature Medicine

Prospective Cohort Study to Compare Long-Term Lung Cancer-Specific and All-Cause Survival of Clinical Early Stage (T1a–b; ≤20 mm) NSCLC Treated by Stereotactic Body Radiation Therapy and Surgery. Claudia I. Henschke, Rowena Yip, Qi Sun, Pengfei Li, Andrew Kaufman, Robert Samstein, Cliff Connery, Leslie Kohman, Paul Lee, Henry Tannous, David F. Yankelevitz, Emanuela Taioli, Kenneth Rosenzweig, Raja M. Flores, Raja Flores, Dong Seok Lee, Daniel Nicastri, Andrea Wolf, Kimberly Song, Jorge Gomez, Pinaki Dutta, Mary Beth Beasley, Maureen Zakowski, Michael Chung, Rebecca Schwartz, Huiwen Chan, Jeffrey Zhu, Sydney Kantor, Sydney Woode, Ardeshir Hakami, Arzu Buyuk, Adie Friedman, Ronald Dreifuss, Stacey Verzosa, Mariya Yakubox, Karina Aloferdova, Patricia Stacey, Simone De Nobrega, Lauren Lentini, Harvey Pass, Benjamin Cooper, Andre Moreirea, Audrey Sorensen, Robert Dunton, Jason Wallen, Christopher Curtiss, Cliff P. Connery, Artit Jirapatnakul, Robert Korst, Mary Salvatore. Journal of Thoracic Oncology

View All Publications

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Samstein has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.