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Rauf Latif, PhD

img_Rauf Latif
ASSOCIATE PROFESSOR | Pharmacological Sciences
646-725-1641
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The thyroid stimulating hormone receptor (TSHR) expressed on the surface of thyroid epithelial cells is central to the regulation of thyroid growth, development and function. This unique GPCR undergoes complex post-translational processing such as intramolecular cleavage and oligomerization in addition to being localized to lipid rafts. Gaining insight into the regulation and signaling of this thyroid autoantigen is important pathophysiologically because of its extended presence in other extra-thyroidal tissues. Thus TSHR is important in thyroid autoimmunity, thyroid development and other extra-thyroidal conditions

Focus of the laboratory has been on understanding the role of these receptors in post-translational modifications and signaling. The receptors has also been a therapeutic target for the development of novel small molecules.  

 

Ph.D., Institute of Basic Medical Sciences

Indian Institute of Science

Weizmann Institute of Science

2003

Travel Award

The Endocrine Society

2000

Travel Award

The American Thyroid Association

1986

Five year Predoctoral Fellowship

University Grants Commission, India

93
Publications

Selected Publications

Corrigendum to “From discovery to therapeutic development of monoclonal antibodies” [J. Control. Release., Volume 396, 10 August 2026, Article 115034]. Satish Rojekar, Amol D. Gholap, Anusha R. Pallapati, Rauf Latif, Pavimol Angsantikul, Nagavendra Kommineni, Farhath Sultana, Anne Macdonald, Darya Vasilyeva, Steven Sims, Surabhi Parte, Clement Haeck, Rukmani Pandey, Judit Gimenez-Roig, Anisa Gumerova, Uliana Cheliadinova, Georgii Pevnev, Guzel Burganova, Zehra Tumoglu, Maryam Mansoori, Wei Yi, Orly Barak, Susan Hutchison, Francisco Fueyo González, Ki A. Goosens, Weibin Zhou, Vitaly Ryu, Ofer Moldavski, Tal Frolinger, Se Min Kim, Daria Lizneva, Tony Yuen, Mone Zaidi. Journal of Controlled Release

Ligand-induced stability studies at the TSH receptor show the linker region to be a chameleon. Mihaly Mezei, Rauf Latif, Pingping Xiang, Terry F. Davies. Endocrinology (United States)

From discovery to therapeutic development of monoclonal antibodies. Satish Rojekar, Amol D. Gholap, Anusha R. Pallapati, Rauf Latif, Pavimol Angsantikul, Nagavendra Kommineni, Farhath Sultana, Anne Macdonald, Darya Vasilyeva, Steven Sims, Surabhi Parte, Clement Haeck, Rukmani Pandey, Judit Gimenez-Roig, Anisa Gumerova, Uliana Cheliadinova, Georgii Pevnev, Guzel Burganova, Zehra Tumoglu, Maryam Mansoori, Wei Yi, Orly Barak, Susan Hutchison, Francisco Fueyo González, Ki A.Goosens, Weibin Zhou, Vitaly Ryu, Ofer Moldavski, Tal Frolinger, Se Min Kim, Daria Lizneva, Tony Yuen, Mone Zaidi. Journal of Controlled Release

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Atran Berg Laboratory Building Floor 4

1428 Madison Ave

New York, NY 10029

646-725-1641

Thyroid Research Unit Room 2F-30

Bronx, NY 10468

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Latif has not yet completed reporting of industry relationships or has no industry relationships to report.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.