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Ramon Parsons, MD, PhD
img_Ramon Parsons
DIRECTOR, THE TISCH CANCER INSTITUTE
PROFESSOR & CHAIR | Oncological Sciences
PROFESSOR | Medicine, Hematology and Medical Oncology
212-659-5602
email
Research Topics
Cancer, Cancer Genetics, Chromatin, Diabetes, Epigenetics, Epithelial Cells, Gene Regulation, Growth Factors and Receptors, IGF-1 Receptor, Insulin, Insulin Receptor, Knockout Mice, Lipid Signaling, Mass Spectrometry, Microarray, Molecular Biology, Oncogenes, Phosphorylation, Protein Kinases, Protein Phosphatases, Tumor Suppressor Genes, Tumorigenesis
Multi-Disciplinary Training Area
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)
The Parsons laboratory seeks to investigate tumor suppressor and oncogene signaling pathways that are altered in human solid tumors using a multidisciplinary approach that includes genetics, biochemistry, bioinformatics, and pathology.  Thematic topics that are currently under investigation include dissection of the regulation and function of the PTEN tumor suppressor, determination of the impact of altered PTEN signals in cancer progression and altered energy metabolism, molecular pathogenesis of breast carcinoma initiation and progression, and examination of epigenetic and chromatin reprogramming as consequence of altered cancer signal pathways.  Past accomplishments include discovery of PTEN, elucidation of the frequent alteration of the PI3K/PTEN pathway in a wide variety of cancers, generation of mouse models of cancer due to PTEN mutation, and identification of PREX2 as a regulator of PTEN function.

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AB, Columbia University

MD, PhD, State University of New York at Stony Brook

Postdoctoral Training, Johns Hopkins University

2017

Elected, National Academy of Medicine

2015

Elected, Society of Scholars of the Johns Hopkins University

2011

AACR Outstanding Investigator Award for Breast Cancer Research

127
Publications

Selected Publications

Etiology of super-enhancer reprogramming and activation in cancer. Royce W. Zhou, Ramon E. Parsons. Epigenetics and Chromatin

Molecular mechanisms in colitis-associated colorectal cancer. Royce W. Zhou, Noam Harpaz, Steven H. Itzkowitz, Ramon E. Parsons. Oncogenesis

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells. Kaitlyn M. Cahuzac, Abigail Lubin, Kaitlyn Bosch, Nicole Stokes, Sarah Mense Shoenfeld, Royce Zhou, Haddy Lemon, John Asara, Ramon E. Parsons. Cell Reports

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PTEN and Cancer

Icahn (East) Building Floor 1 Room L15C

1425 Madison Ave

New York, NY 10029

212-659-5602

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Parsons during 2023 and/or 2024. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)

  • Therapten, Inc

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.