Rajbhandari Lab is broadly interested in 1) Immune cell regulation of lipid metabolism, 2) developmental process of brown/beige and white fat, and 3) crosstalk between adipose and other metabolic tissues (esp. liver) in the setting of obesity. To address these topics, the lab uses cell and molecular biology, biochemistry, next-gen sequencing (ChIP-, RNA-, ATAC-seq), animal model, single cell/nuclei RNA sequencing, and imaging. The lab seeks to further advance the understanding of human adiposity in collaboration with St. Luke’s Hospital. The broader significance of the work in Rajbhandari Lab is that obesity is linked to various diseases and by studying how cellular and molecular pathways are perturbed in the setting of obesity might provide better understanding of this disease. Visit the Rajbhandari Lab