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Prashant Rajbhandari, PhD
img_Prashant Rajbhandari
ASSISTANT PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
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Research Topics
Adipose, Diabetes, Metabolism
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Rajbhandari Lab is broadly interested in 1) Immune cell regulation of lipid metabolism, 2) developmental process of brown/beige and white fat, and 3) crosstalk between adipose and other metabolic tissues (esp. liver) in the setting of obesity. To address these topics, the lab uses cell and molecular biology, biochemistry, next-gen sequencing (ChIP-, RNA-, ATAC-seq), animal model, single cell/nuclei RNA sequencing, and imaging. The lab seeks to further advance the understanding of human adiposity in collaboration with St. Luke’s Hospital. The broader significance of the work in Rajbhandari Lab is that obesity is linked to various diseases and by studying how cellular and molecular pathways are perturbed in the setting of obesity might provide better understanding of this disease. Visit the Rajbhandari Lab

BA, Olivet College

PhD, University of Wisconsin

Postdoc, University of California-Los Angeles ; Howard Hughes Medical Institute

25
Publications

Selected Publications

Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles. Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu. Genome Medicine

Mammary duct luminal epithelium controls adipocyte thermogenic programme. Sanil Patel, Njeri Z.R. Sparman, Douglas Arneson, Alexandra Alvarsson, Luís C. Santos, Samuel J. Duesman, Alessia Centonze, Ephraim Hathaway, In Sook Ahn, Graciel Diamante, Ingrid Cely, Chung Hwan Cho, Noble Kumar Talari, Abha K. Rajbhandari, Leigh Goedeke, Peng Wang, Atul J. Butte, Cédric Blanpain, Karthickeyan Chella Krishnan, Aldons J. Lusis, Sarah A. Stanley, Xia Yang, Prashant Rajbhandari. Nature

Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs. Lara Bideyan, Maykel López Rodríguez, Christina Priest, John P. Kennelly, Yajing Gao, Alessandra Ferrari, Prashant Rajbhandari, An Chieh Feng, Sergei G. Tevosian, Stephen T. Smale, Peter Tontonoz. Genes and Development

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Atran Berg Laboratory Building Floor 5th Floor Room AB5-12

1428 Madison Ave

New York, NY 10029

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Rajbhandari did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.