Peng Yuan, PhD
img_Peng Yuan
PROFESSOR | Pharmacological Sciences
PROFESSOR | Neuroscience
Research Topics
Biochemistry, Biomedical Sciences, Biophysics, Drug Design and Discovery, Drug Resistance, Membrane Proteins/Channels, Neuroscience, Structural Biology
Multi-Disciplinary Training Area
Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
Drug discovery
We aim to gain a comprehensive understanding of the physicochemical principles of membrane transport and to establish new foundations for mechanism-based rational therapies.
Structure and function of membrane transport proteins
Selective transport of ions, nutrients, and folded proteins across cell membranes, mediated by membrane transport proteins, is a fundamental biological process. We are interested in understanding molecular mechanisms of membrane transport proteins such as ion channels and transporters that play essential roles in physiology and disease. How do ion channels and transporters recognize their specific substrate ions? How do channels open and close their ion conduction pores in response to environmental cues and cellular stimuli such as chemicals, temperature, membrane voltage and mechanical force? To answer these fundamental questions, my lab uses multidisciplinary approaches including electrophysiology, biochemical and biophysical assays, and structural biology. Dysfunction of these membrane proteins leads to a wide range of diseases, including asthma, hypertension, cancer, heart failure, diabetes and chronic pain. Our goal is to advance our understanding of structure and function of these essential membrane proteins at the atomic level.

PhD, University of Pennsylvania

Postdoc, Rockefeller University

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Yuan did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.