Paul Slesinger | Icahn School of Medicine

Biography

Research Topics

Addiction, Biophysics, Electrophysiology, Neurophysiology, Neuroscience, Protein Trafficking & Sorting, Signal Transduction, Synaptic Plasticity

Multi-Disciplinary Training Area

Disease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]

Research

II) Advancing novel techniques for elucidating neuropeptide signaling in the brain

Project: We are developing tools for measuring the real-time release of neuropeptides in freely behaving animals using new biosensors (i.e., CNiFERs) and custom-made Miniscopes. Project: We are developing nanovesicles engineered for photorelease of drugs in vivo in real-time.

III) Human neuronal models of schizophrenia and alcohol use disorder

Project: Investigating the role of GIRK2 function in excitatory neurons in the context of alcohol use disorder, using hiPSC-derived neurons and a combination of electrophysiology, calcium imaging, and transcriptomic analysis. Project: Investigating the impact of the effects of polygenic alterations related to alcohol use disorder (AUD) on the human neuronal function using iPSC-derived excitatory neurons from control individuals and AUD patients.

I) Neural circuits underlying addiction – role of potassium channels.

Project: Investigating the structural and molecular determinants of GIRK channel gating and modulation. Project: Investigating the neuronal activity and neurotransmitter release in the reward circuitry during alcohol intake, using fiber photometry to measure fluorescence in freely moving animals that express genetically encoded calcium and neurotransmitter indicators. Project: Investigating the physiological roles of the GIRK channels in the brain disorders, and developing pharmacological tools to modulate GIRK channels in these disorders.

Education

BA, Reed College

PhD, University of California, San Francisco

Postdoctoral Fellow, University of California, San Francisco

Honors & Awards

2006

NARSAD Independent Investigator Award

2003

McKnight Technological Innovations in Neuroscience Award

2001

Human Frontiers Science Program Young Investigator Grant

1999

McKnight Scholars Award in Neuroscience

1998

Alfred P. Sloan Research Fellow

Publications

127

Publications

Selected Publications

Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. Nicholas C. Green, Hongyu Gao, Xiaona Chu, Qiuyue Yuan, Patrick McGuire, Dongbing Lai, Guanglong Jiang, Xiaoling Xuei, Jill L. Reiter, Julia Stevens, Greg T. Sutherland, Alison M. Goate, Zhiping P. Pang, Paul A. Slesinger, Ronald P. Hart, Jay A. Tischfield, Arpana Agrawal, Yue Wang, Zhana Duren, Howard J. Edenberg, Yunlong Liu. Nature Communications

Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2. Chrystian Junqueira Alves, Theodore Hannah, Sita Sadia, Christy Kolsteeg, Angela Dixon, Robert J. Wiener, Ha Nguyen, Murray J. Tipping, Júlia Silva Ladeira, Paula Fernandes da Costa Franklin, Nathália de Paula Dutra de Nigro, Rodrigo Alves Dias, Priscila V. Zabala Capriles, José P. Rodrigues Furtado de Mendonça, Paul A. Slesinger, Kevin D. Costa, Hongyan Zou, Roland H. Friedel. Nature Communications

Major-depressive-disorder-associated dysregulation of ZBTB7A in orbitofrontal cortex promotes astrocyte-mediated stress susceptibility. Sasha L. Fulton, Jaroslav Bendl, Giuseppina Di Salvo, John F. Fullard, Amni Al-Kachak, Ashley E. Lepack, Andrew F. Stewart, Sumnima Singh, Wolfram F. Poller, Ryan M. Bastle, Mads E. Hauberg, Amanda K. Fakira, Vishwendra Patel, Min Chen, Romain Durand-de Cuttoli, Isabel Gameiro-Ros, Flurin Cathomas, Aarthi Ramakrishnan, Kelly Gleason, Li Shen, Carol A. Tamminga, Ana Milosevic, Scott J. Russo, Filip K. Swirski, Paul A. Slesinger, Ishmail Abdus-Saboor, Robert D. Blitzer, Panos Roussos, Ian Maze. Neuron

View All Publications

Office Locations

Icahn (East) Building Floor 9 Room 20C

1425 Madison Ave

New York, NY 10029

212-659-5438

Icahn (East) Building Floor 9 Room 26,28 (Lab)

1425 Madison Ave

New York, NY 10029

212-659-5942

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Slesinger has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Slesinger has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.