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Michael A Schotsaert, PhD
img_Michael A Schotsaert
ASSOCIATE PROFESSOR | Immunology & Immunotherapy
ASSOCIATE PROFESSOR | Microbiology
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Research Topics
Aging, Antivirals, B Cells, Dendritic Cells, Diabetes, Immunology, Influenza Virus, Interferon, Knockout Mice, Macrophage, Microbiology, Mucosal Immunology, Obesity, SARS Virus, Staphylococcus Aureus, T Cells, Vaccine Development, Viruses and Virology
Multi-Disciplinary Training Area
Microbiology [MIC]
Schotsaert Lab Website
https://labs.icahn.mssm.edu/schotsaertlab/
Adjuvant, antivirals and vaccine research
The Schotsaert laboratory uses its expertise in immunology and preclinical animal models to compare, characterize, validate and optimize new and existing adjuvants, antivirals and vaccines to which it has access through strategic collaborations with other research labs and industry.
Viral infections in the context of comorbidities
More recently we also started studying the impact of comorbidities like advanced age, obesity and diabetes on the host immune response to infection and vaccination in the context of influenza and SARS-CoV-2 (Rathnasinghe, Jangra et al., 2021).
Skewing of host immune responses to infection by pre-existing immunity
The Schotsaert laboratory focuses on how host-immune responses to infection are affected by pre-existing immunity provided by previous infection and/or vaccination. We have previously shown that the host immune response to influenza infection and Staphylococcus superinfection is different in vaccinated versus unvaccinated mice, and can affect protection during reinfection (Choi et al., 2019, 2020). We are currently investigating the immunological mechanisms that underlie this immune skewing by vaccination with a strong focus on myeloid cell biology.
SARS-CoV-2 research
We have established preclinical infection models for SARS-CoV-2 (Syrian Golden hamster and mice) to evaluate vaccines and adjuvants and to immunologically characterize host immune responses to vaccination and infection with the aim to find immune-correlates of protection (Rathnasinghe et al., 2020, Rathnasinghe, Jangra et al., 2021). We have established pipelines to study immune escape by SARS-CoV-2 variants of concern using microneutralization assays and animal vaccination/challenge models (Jangra et al., 2021).

PhD in molecular biotechnology, Ghent University

master's in bio-engineering sciences, Ghent University

master's in molecular medical biotechnology, Ghent University

106
Publications

Selected Publications

Impact of FcRn antagonism on vaccine-induced protective immune responses against viral challenge in COVID-19 and influenza mouse vaccination models. Prajakta Warang, Gagandeep Singh, Mahan Moshir, Ornella Binazon, Gabriel Laghlali, Lauren A. Chang, Heidi Wouters, Peter Vanhoenacker, Margo Notebaert, Nadia Elhemdaoui, Kateřina Augustynková, Sophie Steeland, Peter Ulrichts, Judith Baumeister, Michael Schotsaert. Human Vaccines and Immunotherapeutics

Targeting mTOR in myeloid cells prevents infection-associated inflammation. Yohana C. Toner, Jazz Munitz, Geoffrey Prevot, Judit Morla-Folch, William Wang, Yuri van Elsas, Bram Priem, Jeroen Deckers, Tom Anbergen, Thijs J. Beldman, Eliane E.S. Brechbühl, Muhammed D. Aksu, Athanasios Ziogas, Sebastian A. Sarlea, Mumin Ozturk, Zhenhua Zhang, Wenchao Li, Yang Li, Alexander Maier, Jessica C. Fernandes, Glenn A.O. Cremers, Bas van Genabeek, Joost H.C.M. Kreijtz, Esther Lutgens, Niels P. Riksen, Henk M. Janssen, Serge H.M. Söntjens, Freek J.M. Hoeben, Ewelina Kluza, Gagandeep Singh, Evangelos J. Giamarellos-Bourboulis, Michael Schotsaert, Raphaël Duivenvoorden, Roy van der Meel, Leo A.B. Joosten, Lei Cai, Ryan E. Temel, Zahi A. Fayad, Musa M. Mhlanga, Mandy M.T. van Leent, Abraham J.P. Teunissen, Mihai G. Netea, Willem J.M. Mulder. iScience

Correction to: Virus-induced senescence is a driver and therapeutic target in COVID-19 (Nature, (2021), 599, 7884, (283-289), 10.1038/s41586-021-03995-1). Soyoung Lee, Yong Yu, Jakob Trimpert, Fahad Benthani, Mario Mairhofer, Paulina Richter-Pechanska, Emanuel Wyler, Dimitri Belenki, Sabine Kaltenbrunner, Maria Pammer, Lea Kausche, Theresa C. Firsching, Kristina Dietert, Michael Schotsaert, Carles Martínez-Romero, Gagandeep Singh, Séverine Kunz, Daniela Niemeyer, Riad Ghanem, Helmut J.F. Salzer, Christian Paar, Michael Mülleder, Melissa Uccellini, Edward G. Michaelis, Amjad Khan, Andrea Lau, Martin Schönlein, Anna Habringer, Josef Tomasits, Julia M. Adler, Susanne Kimeswenger, Achim D. Gruber, Wolfram Hoetzenecker, Herta Steinkellner, Bettina Purfürst, Reinhard Motz, Francesco Di Pierro, Bernd Lamprecht, Nikolaus Osterrieder, Markus Landthaler, Christian Drosten, Adolfo García-Sastre, Rupert Langer, Markus Ralser, Roland Eils, Maurice Reimann, Dorothy N.Y. Fan, Clemens A. Schmitt. Nature

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Annenberg Building Floor 15th floor Room 15-14C

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Schotsaert has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.