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Michael A Schotsaert, PhD
img_Michael A Schotsaert
ASSOCIATE PROFESSOR | Immunology & Immunotherapy
ASSOCIATE PROFESSOR | Microbiology
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Research Topics
Aging, Antivirals, B Cells, Dendritic Cells, Diabetes, Immunology, Influenza Virus, Interferon, Knockout Mice, Macrophage, Microbiology, Mucosal Immunology, Obesity, SARS Virus, Staphylococcus Aureus, T Cells, Vaccine Development, Viruses and Virology
Multi-Disciplinary Training Area
Microbiology [MIC]
Adjuvant, antivirals and vaccine research
The Schotsaert laboratory uses its expertise in immunology and preclinical animal models to compare, characterize, validate and optimize new and existing adjuvants, antivirals and vaccines to which it has access through strategic collaborations with other research labs and industry.
Schotsaert Lab Website
https://labs.icahn.mssm.edu/schotsaertlab/
Skewing of host immune responses to infection by pre-existing immunity
The Schotsaert laboratory focuses on how host-immune responses to infection are affected by pre-existing immunity provided by previous infection and/or vaccination. We have previously shown that the host immune response to influenza infection and Staphylococcus superinfection is different in vaccinated versus unvaccinated mice, and can affect protection during reinfection (Choi et al., 2019, 2020). We are currently investigating the immunological mechanisms that underlie this immune skewing by vaccination with a strong focus on myeloid cell biology.
SARS-CoV-2 research
We have established preclinical infection models for SARS-CoV-2 (Syrian Golden hamster and mice) to evaluate vaccines and adjuvants and to immunologically characterize host immune responses to vaccination and infection with the aim to find immune-correlates of protection (Rathnasinghe et al., 2020, Rathnasinghe, Jangra et al., 2021). We have established pipelines to study immune escape by SARS-CoV-2 variants of concern using microneutralization assays and animal vaccination/challenge models (Jangra et al., 2021).
Viral infections in the context of comorbidities
More recently we also started studying the impact of comorbidities like advanced age, obesity and diabetes on the host immune response to infection and vaccination in the context of influenza and SARS-CoV-2 (Rathnasinghe, Jangra et al., 2021).

PhD in molecular biotechnology, Ghent University

master's in bio-engineering sciences, Ghent University

master's in molecular medical biotechnology, Ghent University

95
Publications

Selected Publications

Sequential immunization with chimeric hemagglutinin ΔNS1 attenuated influenza vaccines induces broad humoral and cellular immunity. Raveen Rathnasinghe, Lauren A. Chang, Rebecca Pearl, Sonia Jangra, Amy Aspelund, Alaura Hoag, Soner Yildiz, Ignacio Mena, Weina Sun, Madhumathi Loganathan, Nicholas Alexander Crossland, Hans P. Gertje, Anna Elise Tseng, Sadaf Aslam, Randy A. Albrecht, Peter Palese, Florian Krammer, Michael Schotsaert, Thomas Muster, Adolfo García-Sastre. npj Vaccines

Ally, adversary, or arbitrator? The context-dependent role of eosinophils in vaccination for respiratory viruses and subsequent breakthrough infections. Lauren A. Chang, Michael Schotsaert. Journal of Leukocyte Biology

Correction to: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing (Nature, (2020), 586, 7827, (113-119), 10.1038/s41586-020-2577-1). Laura Riva, Shuofeng Yuan, Xin Yin, Laura Martin-Sancho, Naoko Matsunaga, Lars Pache, Sebastian Burgstaller-Muehlbacher, Paul D. De Jesus, Peter Teriete, Mitchell V. Hull, Max W. Chang, Jasper Fuk Woo Chan, Jianli Cao, Vincent Kwok Man Poon, Kristina M. Herbert, Kuoyuan Cheng, Tu Trinh H. Nguyen, Andrey Rubanov, Yuan Pu, Courtney Nguyen, Angela Choi, Raveen Rathnasinghe, Michael Schotsaert, Lisa Miorin, Marion Dejosez, Thomas P. Zwaka, Ko Yung Sit, Luis Martinez-Sobrido, Wen Chun Liu, Kris M. White, Mackenzie E. Chapman, Emma K. Lendy, Richard J. Glynne, Randy Albrecht, Eytan Ruppin, Andrew D. Mesecar, Jeffrey R. Johnson, Christopher Benner, Ren Sun, Peter G. Schultz, Andrew I. Su, Adolfo García-Sastre, Arnab K. Chatterjee, Kwok Yung Yuen, Sumit K. Chanda. Nature

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Annenberg Building Floor 15th Floor Room 15-14C

1468 Madison Ave

New York, NY 10029

Annenberg Building Floor 15th floor Room 15-14C

1468 Madison Ave

New York, NY 10029

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Schotsaert has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.