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Meng Wu, PhD
img_Meng Wu
ASSISTANT PROFESSOR | Genetics and Genomic Sciences
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Research Topics
Bone Biology, Cartilage Biology, Chromatin, Developmental Biology, Epigenetics, Epigenomics, Folates, Gene Expressions, Gene Regulation, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Molecular Biology, Stem Cells, Structural Biology, Systems Biology, Transcription Factors
Multi-Disciplinary Training Area
Development Regeneration and Stem Cells [DRS]
Folate Pathway and Neural Tube Defects
Neural tube defects (NTDs) are birth defects of the brain and spinal cord. They are a major cause of death and lifelong disability worldwide. Folic acid is known to reduce the risk of a pregnancy being affected by a neural tube defect but it is unclear how folate metabolism is involved in neural tube development. Folate responsive and non-folate responsive NTD mouse models are used for transcriptome and epigenome profiling in neural tubes to explore the molecular pathogenesis of folate pathway-related NTDs.
Study of the Limb Defects in Roberts Syndrome
Roberts syndrome (RBS) is a rare genetic disorder characterized by limb and facial abnormalities. RBS is caused by mutations in the ESCO2 gene, which encodes a protein belonging to the Eco1/Ctf7 family of acetyltransferases. We are using an Esco2 conditional knock out mouse model as well as patient-derived iPS cells to study the limb reduction defects in this syndrome and the pathogenic mechanism of mutant ESCO2.
Craniosynostosis Network
Craniosynostosis Network is an organized and synergistic research program to understand the genetic basis and developmental mechanism of craniosynostosis (http://labs.icahn.mssm.edu/peterlab/craniosynostosis-network/). Project III: Systems Biology of Bone in Coronal Nonsyndromic Craniosynostosis We generate and differentiate patient-derived iPS cells and analyze the transcriptomic profiles during osteogenic differentiation to study systems biology of coronal nonsyndromic craniosynostosis (cNSC). An in vitro osteogenic differentiation model has been developed and high-throughput RNA-seq datasets on human normal and cNSC mesenchymal cells, preosteoblasts and osteoblasts are used to capture the genetic regulation of gene expression and guide network construction.

Postdoctoral Fellow, Icahn School of Medicine at Mount Sinai

BS, Zhejiang University

PhD, Peking Union Medical College

17
Publications

Selected Publications

Limb reduction in an Esco2 cohesinopathy mouse model is mediated by p53-dependent apoptosis and vascular disruption. Arielle S. Strasser, Ana Silvia Gonzalez-Reiche, Xianxiao Zhou, Braulio Valdebenito-Maturana, Xiaoqian Ye, Bin Zhang, Meng Wu, Harm van Bakel, Ethylin Wang Jabs. Nature Communications

Regulatory elements in SEM1-DLX5-DLX6 (7q21.3) locus contribute to genetic control of coronal nonsyndromic craniosynostosis and bone density-related traits. Paola Nicoletti, Samreen Zafer, Lital Matok, Inbar Irron, Meidva Patrick, Rotem Haklai, John Erol Evangelista, Giacomo B. Marino, Avi Ma'ayan, Anshuman Sewda, Greg Holmes, Sierra R. Britton, Won Jun Lee, Meng Wu, Ying Ru, Eric Arnaud, Lorenzo Botto, Lawrence C. Brody, Jo C. Byren, Michele Caggana, Suzan L. Carmichael, Deirdre Cilliers, Kristin Conway, Karen Crawford, Araceli Cuellar, Federico Di Rocco, Michael Engel, Jeffrey Fearon, Marcia L. Feldkamp, Richard Finnell, Sarah Fisher, Christian Freudlsperger, Gemma Garcia-Fructuoso, Rhinda Hagge, Yann Heuzé, Raymond J. Harshbarger, Charlotte Hobbs, Meredith Howley, Mary M. Jenkins, David Johnson, Cristina M. Justice, Alex Kane, Denise Kay, Arun Kumar Gosain, Peter Langlois, Laurence Legal-Mallet, Angela E. Lin, James L. Mills, Jenny E.V. Morton, Peter Noons, Andrew Olshan, John Persing, Julie M. Phipps, Richard Redett, Jennita Reefhuis, Elias Rizk, Thomas D. Samson, Gary M. Shaw, Robert Sicko, Nataliya Smith, David Staffenberg, Joan Stoler, Elizabeth Sweeney, Peter J. Taub, Andrew T. Timberlake, Jolanta Topczewska, Steven A. Wall, Alexander F. Wilson, Louise C. Wilson, Simeon A. Boyadjiev, Andrew O.M. Wilkie, Joan T. Richtsmeier, Ethylin Wang Jabs, Paul A. Romitti, David Karasik, Ramon Y. Birnbaum, Inga Peter. Genetics in Medicine Open

Conunetr: A Conditional Transformer Network for 3D Micro-Ct Embryonic Cartilage Segmentation. Nishchal Sapkota, Yejia Zhang, Susan M. Motch Perrine, Yuhan Hsi, Sirui Li, Meng Wu, Greg Holmes, Abdul R. Abdulai, Ethylin W. Jabs, Joan T. Richtsmeier, Danny Z. Chen.

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Icahn (East) Building Floor 14 Room 52-A

1425 Madison Ave

New York, NY 10029

Icahn (East) Building Floor 14 Room 52A

1425 Madison Ave

New York, NY 10029

212-659-8538

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Wu did not report having any of the following types of financial relationships with industry and other outside entities during 2023 and/or 2024: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

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