Find Faculty

Megan L Shaw, PhD

img_Megan L Shaw
ADJUNCT ASSOCIATE PROFESSOR | Microbiology
email
Research Topics
Antivirals, Biodefense, Immune Antagonism, Infectious Disease, Influenza Virus, Nipah Virus, Viruses and Virology
Multi-Disciplinary Training Area
Microbiology [MIC]

The Shaw laboratory is interested in the interactions that occur between RNA viruses and their hosts at the molecular level and how this knowledge may be used for understanding viral pathogenesis and for developing new antiviral drugs. The research involves basic molecular biology and virology techniques combined with RNAi, proteomics and high-throughput screening of small molecular weight compounds.

Our major focus is on identifying new antivirals for influenza virus as well as host proteins that are required by the virus and therefore may serve as novel drug targets.  Another interest of the Shaw lab is the host antiviral response and specifically the mechanisms that viruses use to block this response. One virus of particular interest to us is Nipah virus, with is a highly pathogenic, emerging paramyxovirus. Nipah virus encodes multiple proteins that inhibit the antiviral response and our goal is to determine their mechanisms of action and their individual contributions to virus pathogenesis.

Students: Leighland Feinman, Nicole Glennon, Grant Beyleveld, Ryan O'Hanlon

Postdoctoral fellows: Oliver Dibben, Ph.D., Yuhong Liang, Ph.D., Kris White, Ph.D., Matthew Urbanowski, Ph.D., Thibaut Vausselin, Ph.D.

Research Personnel: Pablo Abreu Jr., Payal Pradhan

B.Sc., University of Cape Town

B.Sc. (Med)Honors, University of Cape Town

Ph.D., University of Glasgow

53
Publications

Selected Publications

Frequency, kinetics and determinants of viable SARS-CoV-2 in bioaerosols from ambulatory COVID-19 patients infected with the Beta, Delta or Omicron variants. S. Jaumdally, M. Tomasicchio, A. Pooran, A. Esmail, A. Kotze, S. Meier, L. Wilson, S. Oelofse, C. van der Merwe, A. Roomaney, M. Davids, T. Suliman, R. Joseph, T. Perumal, A. Scott, M. Shaw, W. Preiser, C. Williamson, A. Goga, E. Mayne, G. Gray, P. Moore, A. Sigal, J. Limberis, J. Metcalfe, K. Dheda. Nature Communications

Protective efficacy of a plant-produced beta variant rSARS-CoV-2 VLP vaccine in golden Syrian hamsters. Yolandy Lemmer, Ros Chapman, Celia Abolnik, Tanja Smith, Georgia Schäfer, Tandile Hermanus, Ilse du Preez, Kruger Goosen, Kamogelo M. Sepotokele, Sophette Gers, Tasnim Suliman, Wolfgang Preiser, Megan L. Shaw, Robyn Roth, Alma Truyts, John Chipangura, Martin Magwaza, Osborn Mahanjana, Penny L. Moore, Martha M. O'Kennedy. Vaccine

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets. Kelsey M. Haas, Michael J. McGregor, Mehdi Bouhaddou, Benjamin J. Polacco, Eun Young Kim, Thong T. Nguyen, Billy W. Newton, Matthew Urbanowski, Heejin Kim, Michael A.P. Williams, Veronica V. Rezelj, Alexandra Hardy, Andrea Fossati, Erica J. Stevenson, Ellie Sukerman, Tiffany Kim, Sudhir Penugonda, Elena Moreno, Hannes Braberg, Yuan Zhou, Giorgi Metreveli, Bhavya Harjai, Tia A. Tummino, James E. Melnyk, Margaret Soucheray, Jyoti Batra, Lars Pache, Laura Martin-Sancho, Jared Carlson-Stevermer, Alexander S. Jureka, Christopher F. Basler, Kevan M. Shokat, Brian K. Shoichet, Leah P. Shriver, Jeffrey R. Johnson, Megan L. Shaw, Sumit K. Chanda, Dan M. Roden, Tonia C. Carter, Leah C. Kottyan, Rex L. Chisholm, Jennifer A. Pacheco, Maureen E. Smith, Steven J. Schrodi, Randy A. Albrecht, Marco Vignuzzi, Lorena Zuliani-Alvarez, Danielle L. Swaney, Manon Eckhardt, Steven M. Wolinsky, Kris M. White, Judd F. Hultquist, Robyn M. Kaake, Adolfo García-Sastre, Nevan J. Krogan. Nature Communications

View All Publications

1160 5th Ave

New York, NY 10029

Annenberg Building Floor 15 Room 15-14B

1468 Madison Ave

New York, NY 10029

212-241-8931

Annenberg Building Floor 17 Room 17-10A

1468 Madison Ave

New York, NY 10029

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Shaw has not yet completed reporting of industry relationships or has no industry relationships to report.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.