Karen Edelblum, PhD
img_Karen Edelblum
ASSOCIATE PROFESSOR | Pathology, Molecular and Cell Based Medicine
Research Topics
Autoimmunity, Cell Motility, Cellular Immunity, Gastroenterology, Imaging, Immunology, Inflammatory Bowel Disease (IBD), Integrins, Metabolism, Signal Transduction, T Cells
Multi-Disciplinary Training Area
Disease Mechanisms and Therapeutics (DMT), Immunology [IMM]
Edelblum Lab
Our research functions at the intersection between mucosal immunology, cell biology and microbiology to better understand the underlying cause of IBD. By visualizing cellular interactions in real time, we aim to provide new insight into the complexities of intestinal immunity. Through our studies, we hope to develop novel strategies to enhance barrier function in IBD patients to prevent disease relapse. Our primary interest is deciphering the role and regulation of intraepithelial lymphocytes expressing the unconventional gamma delta T cell receptor (gd IELs), which exhibit a largely protective function in the intestinal mucosa. Ongoing NIH-funded studies include investigation of (1) the role of type I interferon and the intestinal microbiota in the regulation of gd IEL function, (2) how CD103 ligation by epithelial E-cadherin contributes to the activation of downstream signaling pathways and effector function in gd IELs, and (3) the role of gd IELs in the onset of ileal Crohn's disease. We leverage unique mouse models, IEL/enteroid co-cultures, multi-omics approaches, intravital microscopy and access to IBD patient specimens to address these questions. http://www.edelblumlab.com

BS, Emory University

PhD, Vanderbilt University

The University of Chicago


American Physiological Society, GI & Liver Section New Investigator Award


Feldstein Medical Foundation Award


Rutgers Biomedical and Health Sciences Chancellor Scholar

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Edelblum has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.