Research Projects Current:
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Kohli-Seth R, Oropello JM, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. A double blind, placebo-controlled, study of E5564, a lipid A antagonist, administered by twice daily intravenous infusions in patients with severe sepsis. \r\n\r\nBenjamin E, Kohli-Seth R, Oropello JM, Leibowitz A, Manasia A, DelGiudice R, Hufanda J. Efficacy and safety of Drotrecogin (Alfa) in adult patients with early severe sepsis \r\n\r\nOropello JM, Kohli-Seth R, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. Central venous access techniques: successful cannulation of central veins upon withdrawal of needle vs. advancement. \r\n\r\nKohli-Seth R, Oropello JM, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. Resting energy expenditure in morbidly obese septic and non-septic patients \r\n\r\nOropello JM, Benjamin E, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. A Phase 2 study to determine the efficacy of Sivelestat in patients with Acute Lung Injury \r\n\r\nBenjamin E Kohli-Seth R, Oropello JM Manasia A, Hannon E, DelGiudice R, Hufanda J Benign postoperative hyperlactatemia in Neurosurgical Patients \r\n\r\nBenjamin E, Oropello JM, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. Beginning and Ending Supportive therapy (BEST) for the Kidney Study \r\nOropello JM, Benjamin E, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. Phase 3 multicenter randomized placebo study of PHP in sepsis with Shock. \r\n\r\nA Manasia, Benjamin E, Oropello JM, R. Kohli-Seth, R DelGiudice, J Hufanda. Limited transthoracic echocardiography (TTE) by non-cardiologist surgical intensivists. \r\n\r\nOropello JM, Benjamin E, Manasia A, R. Kohli-Seth, R DelGiudice, J Hufanda.. J4A-MC-EZZI. A phase 2b Study to determine the efficacy and safety of LY315920 in patients with severe sepsis. \r\n\r\nS. Chhabra, Benjamin E, Oropello JM, Manasia A, Victor Murgolo, R DelGiudice, J Hufanda. Zeroing of hydraulic monitoring systems using laser guidance. \r\n\r\nBenjamin E, Oropello JM, Manasia A, Altschuller-Felberg C, Hufanda J, DelGiudice R: Multicenter, Double Blind, Placebo Controlled, Randomized, Phase III Study of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor [rTFPA/SC-59735]) in Severe Sepsis. \r\n\r\nBenjamin E Oropello JM. Nierman D, Loren S, Hufanda J, DelGiudice R. Prospective study of anemia of critical illness and transfusion is critically ill patients. \r\n\r\nLeibowitz A, Benjamin E, Oropello JM, Manasia, A, DelGiudice R., A randomized, open-labeled, pilot assessment of the effect of Protonix IV for injection (Pantoprazole Sodium) on gastric pH in ICU patients. \r\n\r\nOropello JM, Benjamin E, Altschuller-Felberg C, DelGiudice R, Hufanda J. . Open-label, comparative, randomized multicenter Phase 111 study of iv Synercid vs.Vancomycin or Nafcillin in the treatment of 380 patients with central venous catheter-related bacteremia. \r\n\r\nManasia A, Oropello JM, Benjamin E, Altschuller-Felberg C, DelGiudice R A Phase II, Dose-Ranging Evaluation of Safety and Efficacy of a-hANP for ARDS. \r\n\r\nKohli-Seth, Benjamin E. Oropello JM, Manasia, DelGiudice R, Hufanda J Amede F. The effect of continuous veno-venous hemofiltration (CVVH) on lung water as measured by transthoracic impedance analysis (TBIA). \r\n\r\nOropello JM, Altschuller-Felberg C, Benjamin E, Manasia A, DelGuidice R: rSP-c surfactant for the treatment of acute respiratory distress syndrome (ARDS), a randomized, multicenter, parallel group, controlled pilot study. \r\n\r\nOropello JM, Manasia A, Benjamin E, Altschuller-Felberg C, DelGuidice R: A phase II study to determine the efficacy and safety of LY315920 in patients with severe sepsis. \r\n \r\nBenjamin E, Oropello JM, Manasia A, Altschuller-Felberg C Hufanda, J: Multicenter, single blind, placebo-controlled, randomized, dose escalation study of recombinant tissue factor pathway inhibitor (rTFOI/SC-59735) in severe sepsis. \r\n