John F Crary, MD, PhD
img_John F Crary
PROFESSOR | Pathology, Molecular and Cell Based Medicine
PROFESSOR | Neuroscience
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Anatomic Pathology and Clinical Pathology
Research Topics
Aging, Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Axonal Growth and Degeneration, Biomechanics/Bioengineering, Brain, Cancer, Cell Biology, Cytoskeleton, Drosophila, Genetics, Microtubules, Molecular Biology, Neuro-degeneration/protection, Neurobiology, Parkinson's Disease, Pathology, RNA, RNA Splicing & Processing, RNA Transport & Localization
Multi-Disciplinary Training Area
Neuroscience [NEU]
Crary Laboratory Our research focuses on the molecular neuropathology of neurodegenerative diseases. Using an interdisciplinary approach, we are unravelling the molecular changes occurring in diseases with neurofibrillary tangles composed of the tau protein (i.e., tauopathies). This diverse set of brain diseases includes dementias, such as Alzheimer's disease, movement disorders, such as Parkinson's disease and related conditions, and the long-term sequelae of repetitive traumatic brain injury, or chronic traumatic encephalopathy. We are using histological, genetic, biochemical and molecular approaches to pinpoint underlying molecular and cellular triggers of these diseases. Recently, we have begun to deploy powerful artificial intelligence (machine learning)-based approaches, including computer vision, which is revolutionizing our approach to neurodegeneration. Major ongoing NIH-funded projects in the laboratory include: • Clinical, histopathological, biochemical and genetic studies of primary age-related tauopathy (R01NS095252) • Regulation of tau expression in Alzheimer's disease and aging (R01AG054008) • Clinicopathological studies of chronic traumatic encephalopathy (R01AG062348) • Clinicopathological studies of age-related neurodegeneration in HIV/AIDS (RF1AG060961)
Neuropathology Brain Bank and Research CoRE Research conducted using human post-mortem brain tissue remains a critical component of translational brain research programs. To meet the urgent need for this precious resource, the Neuropathology Brain Bank and Research CoRE was launched as part of the Mount Sinai Strategic Plan in July 2018.

MD, SUNY Downstate Health Sciences University - College of Medicine

Residency, Pathology, Columbia University Irving Medical Center

Fellowship, Neuropathology, Columbia University Irving Medical Center


American Board of Pathology

Selected Publications

Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy. Michael L. Alosco, Micaela White, Carter Bell, Farwa Faheem, Yorghos Tripodis, Eukyung Yhang, Zachary Baucom, Brett Martin, Joseph Palmisano, Kristen Dams-O’Connor, John F. Crary, Lee E. Goldstein, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Victor E. Alvarez, Bertrand Russell Huber, Thor D. Stein, Ann C. McKee, Jesse Mez. Molecular Neurodegeneration

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model. Gustavo Morrone Parfitt, Elena Coccia, Camille Goldman, Kristen Whitney, Ricardo Reyes, Lily Sarrafha, Ki Hong Nam, Soha Sohail, Drew R. Jones, John F. Crary, Alban Ordureau, Joel Blanchard, Tim Ahfeldt. Nature Communications

Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy. Julia E. Culhane, Colleen E. Jackson, Yorghos Tripodis, Christopher J. Nowinski, Kristen Dams-O'Connor, Erika Pettway, Madeline Uretsky, Bobak Abdolmohammadi, Evan Nair, Brett Martin, Joseph Palmisano, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Lee E. Goldstein, Neil W. Kowall, Robert C. Cantu, Robert A. Stern, Bertrand Russell Huber, John F. Crary, Jesse Mez, Thor D. Stein, Ann C. McKee, Michael L. Alosco. Journal of Neurotrauma

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Crary has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.