Manhattan HIV Brain Bank (NIH U24 MH100931
This is a longitudinal organ donation study examining the neurologic, neuropsychological, psychiatric, and pathological effects of HIV. Role: Co-investigator and medical director
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center (NIH U24 NS113849)
This grant supports infrastructure to maintain a clinical trial site in readiness to participate in early phase clinical trials in pain. Role: Principal Investigator
Toward safer opioid prescribing for chronic pain in high risk populations: implementing the Centers for Disease Control Guideline (CDC) guideline in the primary care HIV clinic. (AHRQ R18 HS025641)
This study seeks to determine the best way of supporting HIV primary care providers in adopting safer opioid prescribing practices. Role: Principal Investigator
Motor Dysfunction in cART-era HIV: Neural Circuitry and Pathogenesis (NIH R01NS108801)
We will identify brain regions associated with motor dysfunction by a neuroimaging study, examine cell-specific molecular changes in these regions by neurogenomics, and relate molecular signatures to regional inflammation and vascular disease, in order to discover potential targets for therapy. Role: Co-investigator
Hippocampal Inflammation as a Pathophysiology for Psychosis (NIH R01MH110418)
This grant explores the role of the gut-brain axis in psychosis with a focus on vagal dysfunction. Role: Co-investigator
Mount Sinai Network of Excellence in Neuroscience Clinical Trials (NIH U24NS107201)
Mount Sinai is a participating site in NeuroNEXT, a consortium of sites committed to participating in clinical trials of therapeutics for a variety of neurologic conditions. Role: Co-investigator
Alzheimer’s, Cerebrovascular, & Sociocultural Risk Factors for Dementia in HIV (Alzheimer’s Association)
The purpose of this study is to improve the knowledge and understanding of the effects of social,
cultural and genetic factors associated with aging and cognition in people with human
immunodeficiency virus (HIV). Role: Site Principal Investigator
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV (NIH R01DK122853)
This grant examines the relationship between vagal dysfunction, gastrointestinal dysmotility and the cholinergic anti-inflammatory reflex in HIV-associated autonomic neuropathy. Role: Principal Investigator
Study of Aging Latinas/os for Understanding Dementia in HIV (SALUD HIV) (NIH R01AG065110)
This project investigates whether older HIV+ Puerto Rican Latinas/os show worse patterns of decline in cognition and brain integrity compared to other groups and to interrogate the mechanisms conferring risk for these changes. Role: Co-investigator/ISMMS Subaward Principal Investigator
