Jerry Chipuk, PhD
Jerry Edward Chipuk (Preferred Name)
img_Jerry Chipuk
PROFESSOR | Oncological Sciences
PROFESSOR | Graduate Education
PROFESSOR | Dermatology
Research Topics
Anti-Tumor Therapy, Apoptosis/Cell Death, Cancer, Cell Biology, Cell Transformation, Drug Resistance, Imaging, Lipid Signaling, Membrane Proteins/Channels, Membranes, Mitochondria, Molecular Biology, Oncogenes, Protein Kinases, Signal Transduction, Tumor Suppressor Genes, Tumorigenesis
Multi-Disciplinary Training Area
Cancer Biology [CAB]

Our current research interests are divided into three areas, but adopt a unified theme to decipher the interplay between mitochondria and cell death signaling:

I. What are the biochemical, physiological, and structural consequences of protein·protein interactions within the BCL-2 family?

II. How does the mitochondrial environment influence BCL-2 family function and the core cell death machinery?

III. How do oncogenic and tumor suppressor signals intersect with the mitochondrial dynamics machinery to regulate tumorigenesis and chemosensitivity?

We explore the above questions using state-of-the-art apoptosis, metabolism, and cancer biology model systems --- usually focusing on hematological malignancies and melanoma.

Visit the Chipuk Laboratory

BS, Baldwin-Wallace College

PhD, Case Western Reserve University

Postdoctoral Training, La Jolla Institute for Allergy and Immunology

Postdoctoral Training, St. Jude Children’s Research Hospital

2016

Career Development Award

Leukemia & Lymphoma Society

2015

Research Scholar Grant

American Cancer Society

2015

Research Award

Irma T. Hirschl / Monique Weill-Caulier Research Trusts

2014

Dr. Harold and Golden Lamport Research Award

2013

Basil O'Connor Phase-In Award

March of Dimes

2012

Young Scientist Cancer Research Fund

JJR Foundation

2011

Basil O'Connor Award

March of Dimes

2003

Ruth Kirschstein NRSA

National Institutes of Health

Publications

Selected Publications

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia. Ke Wang, Shayan Saniei, Nikita Poddar, Isabella G. Martinez, Clifford Chao, Subrina Autar, Persephone Fiore, Saul Carcamo, Meghana Sreenath, Jack H. Peplinski, Rhonda E. Ries, Anna Huo Chang Mei, Noshin Azra Rahman, Levan Mekerishvili, Miguel Quijada-Álamo, Grace Freed, Mimi Zhang, Katherine Lachman, Zayna Diaz, Manuel M. Gonzalez, Jing Zhang, Giang Pham, Dan Filipescu, Mirela Berisa, Tommaso Balestra, Noelle Wheeler, Julie A. Reisz, Angelo D'Alessandro, Daniel J. Puleston, Emily Bernstein, Jerry E. Chipuk, Mark Wunderlich, Sarah K. Tasian, Bridget K. Marcellino, Ian A. Glass, Christopher M. Sturgeon, Dan A. Landau, Zhihong Chen, Eirini P. Papapetrou, Franco Izzo, Soheil Meshinchi, Dan Hasson, Elvin Wagenblast. Cancer Discovery

Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival. Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, Jo Ann Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou, Masha V. Poyurovsky, Jerry Edward Chipuk. Cell Communication and Signaling

Resolvin D1-mediated cellular crosstalk protects against MASH. Amaia Navarro-Corcuera, Yiwei Zhu, Fanglin Ma, Neha Gupta, Haley Asplund, Bruno Cogliati, Jerry E. Chipuk, Oren Rom, Scott L. Friedman, Brian E. Sansbury, Xin Huang, Bishuang Cai. JHEP Reports

View All Publications

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Chipuk has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.