Hideo Watanabe, MD, PhD
img_Hideo Watanabe
ASSOCIATE PROFESSOR | Medicine, Pulmonary, Critical Care and Sleep Medicine
ASSOCIATE PROFESSOR | Genetics and Genomic Sciences
Research Topics
Cancer, Cancer Genetics, Cellular Differentiation, Chromatin, Gene Regulation, Genomics, Lung, Molecular Biology
Multi-Disciplinary Training Area
Cancer Biology [CAB]
Transcriptional Programs of Lung Cancer
The Watanabe lab's primary interest is to understand the transcriptional programs of lung cancer. Our group uses functional genomics technologies including RNA sequencing and ChIP sequencing combined with single cell genome technologies to characterize lineage programs governing lung cancers. Keyword: Cancer, Cancer Genetics, Cellular Differentiation, Chromatin, Epigenetics, Gene Regulation, Genomics, Lung, Molecular Biology, Transcription Factors

MD, Keio University School of Medicine

PhD, Keio University Graduate School of Medicine

Broad Institute

Dana-Farber Cancer Institute

Publications

Selected Publications

Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells. Atsuho Morita, Makoto Ishii, Takanori Asakura, Masaya Yotsukura, Ahmed E. Hegab, Tatsuya Kusumoto, Ho Namkoong, Takunori Ogawa, Yuhki Nakatake, Mayumi Oda, Fumitake Saito, Hirofumi Kamata, Junko Hamamoto, Satoshi Okamori, Toshiki Ebisudani, Hiroyuki Yasuda, Shinya Sugimoto, Yuta Kuze, Masahide Seki, Yutaka Suzuki, Naoki Hasegawa, Hisao Asamura, Hideo Watanabe, Minoru Ko, Toshiro Sato, Masaki Ieda, Koichi Fukunaga. npj Regenerative Medicine

Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer. Seungyeul Yoo, Ayushi S. Patel, Sarah Karam, Yi Zhong, Li Wang, Feng Jiang, Ranran Kong, Sharon Bikvan, Wenhui Wang, Abhilasha Sinha, Charles A. Powell, Jun Zhu, Hideo Watanabe. Journal of Hematology and Oncology

TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy. Leanne G. Ahronian, Soumyadip Sahu, Minjie Zhang, Ayushi S. Patel, Ke Geng, Reshmee Bhattacharya, Gerald S. Falchook, Jonathan W. Goldman, Alexander I. Spira, Salman R. Punekar, David R. Spigel, Judy S. Wang, Ferdinandos Skoulidis, Janaye Stephens, Mary Meynardie, Jaylen M. Powell, Alfonso Lopez, Michela Ranieri, Magdalena A. Ploszaj, Yi Jer Tan, Yeuan Ting Lee, Yi Yu, Jiehui Deng, Ting Chen, Patrick McCarren, Alice Tsai, Suleman S. Hussain, Brian Doyon, Kenjie Amemiya, Jacques Ermolieff, Preksha Shahagadkar, Nikitha M. Das, Lauren R. Flynn, Julie A. Shields, Laney Danielczyk, Brian J. McMillan, Andre Mignault, Samuel R. Meier, Hsin Jung Wu, David J. Guerin, Douglas A. Whittington, Chengyin Min, Iga Sienczylo, John P. Maxwell, Heather J. DiBenedetto, Hideo Watanabe, Brian B. Haines, Alan Huang, Adam Crystal, Jannik N. Andersen, Xinyuan Wu, Kwok Kin Wong. Cancer Research

View All Publications

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Watanabe did not report having any of the following types of financial relationships with industry and other outside entities during 2025 and/or 2026: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.