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Guo-Cheng Yuan, PhD
img_Guo-Cheng Yuan
PROFESSOR | Genetics and Genomic Sciences
212-241-3456
email
Research Topics
Bioinformatics, Brain, Cancer, Chromatin, Computational Biology, Epigenomics, Gene Regulation, Genomics, Immunology, Systems Biology
Multi-Disciplinary Training Area
Artificial Intelligence and Emerging Technologies in Medicine [AIET], Genetics and Genomic Sciences [GGS]
Epigenetic regulation
We develop computational methods to analyze various genome-wide assays to characterize the structural organization and regulatory role of chromatin in development and diseases.
Single-Cell Analysis
We develop computational methods to analyze and integrate single-cell multi-omic data with the aim to systematically characterize the landscape of cellular states and investigate the underlying regulatory mechanisms.
Spatial Transcriptomics
We develop computational methods to comprehensively analyze spatial data and user-friendly, generally applicable software packages and apply these tools to dissect tissue structure and investigate the role of environment in mediating cellular activities.

PhD, University of Maryland

Postdoc, Harvard University

148
Publications

Selected Publications

Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Pingzhu Zhou, Nathan J. VanDusen, Yanchun Zhang, Yangpo Cao, Isha Sethi, Rong Hu, Shuo Zhang, Guangyu Wang, Lincai Ye, Neil Mazumdar, Jian Chen, Xiaoran Zhang, Yuxuan Guo, Bin Li, Qing Ma, Julianna Y. Lee, Weiliang Gu, Guo Cheng Yuan, Bing Ren, Kaifu Chen, William T. Pu. Developmental Cell

Construction of a cross-species cell landscape at single-cell level. Renying Wang, Peijing Zhang, Jingjing Wang, Lifeng Ma, E. Weigao, Shengbao Suo, Mengmeng Jiang, Jiaqi Li, Haide Chen, Huiyu Sun, Lijiang Fei, Ziming Zhou, Yincong Zhou, Yao Chen, Weiqi Zhang, Xinru Wang, Yuqing Mei, Zhongyi Sun, Chengxuan Yu, Jikai Shao, Yuting Fu, Yanyu Xiao, Fang Ye, Xing Fang, Hanyu Wu, Qile Guo, Xiunan Fang, Xia Li, Xianzhi Gao, Dan Wang, Peng Fei Xu, Rui Zeng, Gang Xu, Lijun Zhu, Lie Wang, Jing Qu, Dan Zhang, Hongwei Ouyang, He Huang, Ming Chen, Shyh Chang Ng, Guang Hui Liu, Guo Cheng Yuan, Guoji Guo, Xiaoping Han. Nucleic Acids Research

Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells. Guyu Qin, Eun Sil Park, Xueqing Chen, Sen Han, Dongxi Xiang, Fang Ren, Gang Liu, Huidong Chen, Guo Cheng Yuan, Zhe Li. iScience

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Annenberg Building Floor 18 Room 100A

1468 Madison Ave

New York, NY 10029

212-241-3456

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Yuan did not report having any of the following types of financial relationships with industry during 2022 and/or 2023: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.