Filip Swirski, PhD
img_Filip Swirski
PROFESSOR | Medicine, Cardiology
PROFESSOR | Diagnostic, Molecular and Interventional Radiology
Research Topics
Alzheimer's Disease, Autoimmunity, B Cells, Blood, Brain, Cardiac Arrest and Resuscitation, Cardiovascular, Cellular Immunity, Chemokines, Chemotaxis, Cytokines, Dendritic Cells, Endocrinology, Hematopoiesis, Immunology, Inflammation, Lung, Lymphocytes, Macrophage, Microglia, Pathology, Sleep Medicine, Stem Cells, Stress, Systems Biology, T Cells, Transgenic Mice, Viruses and Virology
Multi-Disciplinary Training Area
Immunology [IMM], Microbiology [MIC], Neuroscience [NEU]
Systemic Inflammatory Networks and Inter-Organ Communication
Systemic inflammatory networks connect various cardiovascular and metabolic processes. I showed that the spleen produces monocytes by extramedullary hematopoiesis. I provided evidence for the relative contribution of monocyte recruitment and macrophage proliferation atherosclerosis. I identified an on-demand mechanism by which transient monocyte-derived macrophages dispose of erythrocytes and recycle iron. I identified a population of intraepithelial T cells that modulate dietary metabolism and contribute to cardiovascular disease.
Hematopoiesis and Growth Factors
Survival, proliferation, and differentiation of hematopoietic cells it tightly controlled by various cell-specific factors. I discovered a GM-CSF-producing B cell that protect against sepsis and pneumonia. I showed that the growth factor IL-3 aggravates sepsis by eliciting the cytokine storm. I defined a critical role for IL-3 in myocarditis. I demonstrated that T cell output in the thymus relies on liver X receptors.
Monocytes and Macrophages in Cardiovascular Disease
A major long-standing focus is to understand how monocytes and macrophages participate in atherosclerosis and myocardial infarction. I showed that monocytes accumulate continuously in evolving atherosclerotic lesions. I linked atherosclerosis with blood monocytosis. I identified a biphasic monocyte-macrophage response that coordinates healing, and discovered a monocyte reservoir in the spleen. I showed that sleep protects against atherosclerosis by limiting monocyte production.

PhD, McMaster University

Harvard Medical School


ESC William Harvey Lecture on Basic Science

European Society of Cardiology


Tucker Collins Lecture


Leaders in Cardiovascular Science Profile

Circulation Research


Jeffrey M Hoeg Award for Basic Science and Clinical Research


Established Investigator Award



Patricia and Scott Eston MGH Research Scholar


Martin Prize for Fundamental Research


Outstanding Investigator Award



Howard M. Goodman Fellowship

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Dr. Swirski has not yet completed reporting of Industry relationships.

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