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Filip Swirski, PhD
img_Filip Swirski
PROFESSOR | Medicine, Cardiology
PROFESSOR | Diagnostic, Molecular and Interventional Radiology
email
Research Topics
Alzheimer's Disease, Autoimmunity, B Cells, Blood, Brain, Cardiac Arrest and Resuscitation, Cardiovascular, Cellular Immunity, Chemokines, Chemotaxis, Cytokines, Dendritic Cells, Endocrinology, Hematopoiesis, Immunology, Inflammation, Lung, Lymphocytes, Macrophage, Microglia, Pathology, Sleep Medicine, Stem Cells, Stress, Systems Biology, T Cells, Transgenic Mice, Viruses and Virology
Multi-Disciplinary Training Area
Immunology [IMM], Microbiology [MIC], Neuroscience [NEU]
Monocytes and Macrophages in Cardiovascular Disease
A major long-standing focus is to understand how monocytes and macrophages participate in atherosclerosis and myocardial infarction. I showed that monocytes accumulate continuously in evolving atherosclerotic lesions. I linked atherosclerosis with blood monocytosis. I identified a biphasic monocyte-macrophage response that coordinates healing, and discovered a monocyte reservoir in the spleen. I showed that sleep protects against atherosclerosis by limiting monocyte production.
Hematopoiesis and Growth Factors
Survival, proliferation, and differentiation of hematopoietic cells it tightly controlled by various cell-specific factors. I discovered a GM-CSF-producing B cell that protect against sepsis and pneumonia. I showed that the growth factor IL-3 aggravates sepsis by eliciting the cytokine storm. I defined a critical role for IL-3 in myocarditis. I demonstrated that T cell output in the thymus relies on liver X receptors.
Systemic Inflammatory Networks and Inter-Organ Communication
Systemic inflammatory networks connect various cardiovascular and metabolic processes. I showed that the spleen produces monocytes by extramedullary hematopoiesis. I provided evidence for the relative contribution of monocyte recruitment and macrophage proliferation atherosclerosis. I identified an on-demand mechanism by which transient monocyte-derived macrophages dispose of erythrocytes and recycle iron. I identified a population of intraepithelial T cells that modulate dietary metabolism and contribute to cardiovascular disease.

PhD, McMaster University

Harvard Medical School

2020

ESC William Harvey Lecture on Basic Science

European Society of Cardiology

2019

Tucker Collins Lecture

2018

Leaders in Cardiovascular Science Profile

Circulation Research

2017

Established Investigator Award

AHA

2017

Jeffrey M Hoeg Award for Basic Science and Clinical Research

2016

Martin Prize for Fundamental Research

2016

Outstanding Investigator Award

NIH

2016

Patricia and Scott Eston MGH Research Scholar

2005

Howard M. Goodman Fellowship

204
Publications

Selected Publications

Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis. Máté G. Kiss, Nikolina Papac-Miličević, Florentina Porsch, Dimitrios Tsiantoulas, Tim Hendrikx, Minoru Takaoka, Huy Q. Dinh, Marie Sophie Narzt, Laura Göderle, Mária Ozsvár-Kozma, Michael Schuster, Nikolaus Fortelny, Anastasiya Hladik, Sylvia Knapp, Florian Gruber, Matthew C. Pickering, Christoph Bock, Filip K. Swirski, Klaus Ley, Alma Zernecke, Clément Cochain, Claudia Kemper, Ziad Mallat, Christoph J. Binder. Immunity

Recruited macrophages elicit atrial fibrillation. Maarten Hulsmans, Maximilian J. Schloss, I. Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf. Science

Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis. Máté G. Kiss, John E. Mindur, Abi G. Yates, Donghoon Lee, John F. Fullard, Atsushi Anzai, Wolfram C. Poller, Kathleen A. Christie, Yoshiko Iwamoto, Vladimir Roudko, Jeffrey Downey, Christopher T. Chan, Pacific Huynh, Henrike Janssen, Achilles Ntranos, Jan D. Hoffmann, Walter Jacob, Sukanya Goswami, Sumnima Singh, David Leppert, Jens Kuhle, Seunghee Kim-Schulze, Matthias Nahrendorf, Benjamin P. Kleinstiver, Fay Probert, Panos Roussos, Filip K. Swirski, Cameron S. McAlpine. Immunity

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Hess CSM Building Floor 7 Room 117

1470 Madison Ave

New York, NY 10029

Hess CSM Building Floor 7 Room 117

1470 Madison Ave

New York, NY 10029

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Swirski during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting:

  • Verseau Therapeutics

Employment:

  • Massachusetts General Hospital (MGH)

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.