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Filip Swirski, PhD
img_Filip Swirski
PROFESSOR | Medicine, Cardiology
PROFESSOR | Diagnostic, Molecular and Interventional Radiology
PROFESSOR | Immunology & Immunotherapy
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Research Topics
Alzheimer's Disease, Autoimmunity, B Cells, Blood, Brain, Cardiac Arrest and Resuscitation, Cardiovascular, Cellular Immunity, Chemokines, Chemotaxis, Cytokines, Dendritic Cells, Endocrinology, Hematopoiesis, Immunology, Inflammation, Lung, Lymphocytes, Macrophage, Microglia, Pathology, Sleep Medicine, Stem Cells, Stress, Systems Biology, T Cells, Transgenic Mice, Viruses and Virology
Multi-Disciplinary Training Area
Immunology [IMM], Microbiology [MIC], Neuroscience [NEU]
Monocytes and Macrophages in Cardiovascular Disease
A major long-standing focus is to understand how monocytes and macrophages participate in atherosclerosis and myocardial infarction. I showed that monocytes accumulate continuously in evolving atherosclerotic lesions. I linked atherosclerosis with blood monocytosis. I identified a biphasic monocyte-macrophage response that coordinates healing, and discovered a monocyte reservoir in the spleen. I showed that sleep protects against atherosclerosis by limiting monocyte production.
Systemic Inflammatory Networks and Inter-Organ Communication
Systemic inflammatory networks connect various cardiovascular and metabolic processes. I showed that the spleen produces monocytes by extramedullary hematopoiesis. I provided evidence for the relative contribution of monocyte recruitment and macrophage proliferation atherosclerosis. I identified an on-demand mechanism by which transient monocyte-derived macrophages dispose of erythrocytes and recycle iron. I identified a population of intraepithelial T cells that modulate dietary metabolism and contribute to cardiovascular disease.
Hematopoiesis and Growth Factors
Survival, proliferation, and differentiation of hematopoietic cells it tightly controlled by various cell-specific factors. I discovered a GM-CSF-producing B cell that protect against sepsis and pneumonia. I showed that the growth factor IL-3 aggravates sepsis by eliciting the cytokine storm. I defined a critical role for IL-3 in myocarditis. I demonstrated that T cell output in the thymus relies on liver X receptors.

PhD, McMaster University

Harvard Medical School

2020

ESC William Harvey Lecture on Basic Science

European Society of Cardiology

2019

Tucker Collins Lecture

2018

Leaders in Cardiovascular Science Profile

Circulation Research

2017

Jeffrey M Hoeg Award for Basic Science and Clinical Research

2017

Established Investigator Award

AHA

2016

Patricia and Scott Eston MGH Research Scholar

2016

Martin Prize for Fundamental Research

2016

Outstanding Investigator Award

NIH

2005

Howard M. Goodman Fellowship

219
Publications

Selected Publications

Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis. Abi G. Yates, Annie Khamhoung, Lena Gaebel, Walter Jacob, Daniel E. Radford-Smith, Máté G. Kiss, Pacific Huynh, Teresa Gerhardt, Merlin Heiser, Oren Cohen, Filip K. Swirski, Daniel C. Anthony, James Sumowski, Ilana Katz Sand, Cameron S. McAlpine. Nature Communications

Novel Artificial 5′UTR Increase Modified mRNA Translation When Injected into Mouse Heart. Ann Anu Kurian, Matteo Ghiringhelli, Eyal Shalom, Gayatri Mainkar, Magdalena M. Żak, Matthew Adjmi, Jeffrey Downey, Seonghun Yoon, Nicole Dubois, Filip K. Swirski, Lior Zangi. Pharmaceutics

Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function. Hanming Zhang, Diego Sáenz de Urturi, Pablo Fernández-Tussy, Yan Huang, Daniel G. Jovin, Xinbo Zhang, Shushu Huang, Monkol Lek, Jonatas da Silva Catarino, Magdalena Sternak, Kathryn M. Citrin, Fillip K. Swirski, Jan Åke Gustafsson, Daniel M. Greif, Enric Esplugues, Lauren A. Biwer, Yajaira Suárez, Carlos Fernández-Hernando. Proceedings of the National Academy of Sciences of the United States of America

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Hess CSM Building Floor 7 Room 117

1470 Madison Ave

New York, NY 10029

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Swirski has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.