Our main goal at the Systems Bioengineering Lab is to understand mechanobiological decision-making capabilities and to develop novel therapeutics for precision medicine. We employ multiscale experimental and computational techniques as well as microfabrication and tissue engineering methods to study cell signaling, biomechanics, tissue function and regeneration using human induced pluripotent stem cell-derived cardiovascular and renal model systems. We also use multi-platform omics technologies and network analyses for identification of key information processing hubs and regulatory motifs that can be used as therapeutic targets in drug development for complex diseases such as hypertension, diabetic nephropathy and heart failure. See Azeloglu Lab website for more details.