Erwin P Bottinger | Icahn School of Medicine

Biography

Research Topics

Apoptosis/Cell Death, Bioinformatics, Cell Biology, Diabetes, Fibrosis, Genomics, Growth Factors and Receptors, Kidney, Knockout Mice, Signal Transduction

Research

Early pathomechanisms in diabetic nephropathy and non-diabetic kidney diseases

Millions of Americans are affected with chronic diabetic and non-diabetic kidney diseases that cause kidney failure (end stage renal disease). When kidneys fail, the average life expectancy is just over two years and survival depends on costly and disabling dialysis or transplantation treatments.

State-of-the-art genomics and bioinformatics approaches are used to discover and characterize new molecular targets and pathways associated with apoptosis, transdifferentiation, and fibrogenesis in specialized renal cells exposed to diabetic and other stresses. TGF-beta signaling pathways and targets are a major theme because TGF-beta is a key mediator of these processes.

Model systems used include renal cell culture and mouse models of diabetic and non-diabetic progressive renal disease. A new genomic medicine program aims at identification and validation of molecular biomarkers that predict progressive kidney disease in humans.

Education

Nuremberg General Hospital, University of ErIangen-Nuremberg

Cabrini Medical Center

Massachusetts General Hospital and Harvard Medical School

National Cancer Institute, National Institutes of Health

MD, Friedrich-Alexander Universitat School of Medicine, Erlangen-Nurember

Publications

360

Publications

Selected Publications

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database. Sanna Gudmundsson, Moriel Singer-Berk, Sarah L. Stenton, Julia K. Goodrich, Michael W. Wilson, Jonah Einson, Nicholas A. Watts, Xuefang Zhao, Robert Yolken, Mary T. Yohannes, Ramnik J. Xavier, Lauren Witzgall, James G. Wilson, Nicola Whiffin, Christopher Whelan, Maija Wessman, Ben Weisburd, Rinse K. Weersma, Hugh Watkins, James S. Ware, Qingbo Wang, Lily Wang, Arcturus Wang, Mark Walker, Gordon Wade, Christopher Vittal, Elisabet Vilella, Severine Vermeire, Marquis Vawter, Erkki Vartiainen, Teresa Tusie-Luna, Dan Turner, Tiinamaija Tuomi, Ming Tsuang, Charlotte Tolonen, Kathleen Tibbetts, Grace Tiao, Yik Ying Teo, Kent D. Taylor, Yekaterina Tarasova, Michael E. Talkowski, E. Shyong Tai, Jaana Suvisaari, Patrick F. Sullivan, Nathan O. Stitziel, Christine Stevens, Chelsea Lowther, Eimear E. Kenny, Erwin P. Bottinger, Maria Abreu. Nature Communications

Keyword-optimized template insertion for clinical note classification via prompt-based learning. Eugenia Alleva, Isotta Landi, Leslee J. Shaw, Erwin Böttinger, Ipek Ensari, Thomas J. Fuchs. BMC Medical Informatics and Decision Making

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits. Lauren E. Petty, Hung Hsin Chen, Elizabeth G. Frankel, Wanying Zhu, Carolina G. Downie, Mariaelisa Graff, Phillip Lin, Priya Sharma, Xinruo Zhang, Alyssa C. Scartozzi, Rashedeh Roshani, Joshua M. Landman, Michael Boehnke, Donald W. Bowden, John C. Chambers, Anubha Mahajan, Mark I. McCarthy, Maggie C.Y. Ng, Xueling Sim, Cassandra N. Spracklen, Weihua Zhang, Michael Preuss, Erwin P. Bottinger, Girish N. Nadkarni, Ruth J.F. Loos, Yii Der Ida Chen, Jingyi Tan, Eli Ipp, Pauline Genter, Leslie S. Emery, Tin Louie, Tamar Sofer, Adrienne M. Stilp, Kent D. Taylor, Anny H. Xiang, Thomas A. Buchanan, Kathryn Roll, Chuan Gao, Nicholette D. Palmer, Jill M. Norris, Lynne E. Wagenknecht, Darryl Nousome, Rohit Varma, Roberta McKean-Cowdin, Xiuqing Guo, Yang Hai, Willa Hsueh, Kevin Sandow, Esteban J. Parra, Susan K. Fried. Nature Communications

View All Publications

Office Locations

Annenberg Building Floor 18 Room 16

1468 Madison Ave

New York, NY 10029

212-241-0800

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Bottinger has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Bottinger has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.