Erwin P Bottinger | Mount Sinai

Biography

Research Topics

Apoptosis/Cell Death, Bioinformatics, Cell Biology, Diabetes, Fibrosis, Genomics, Growth Factors and Receptors, Kidney, Knockout Mice, Signal Transduction

Research

Early pathomechanisms in diabetic nephropathy and non-diabetic kidney diseases

Millions of Americans are affected with chronic diabetic and non-diabetic kidney diseases that cause kidney failure (end stage renal disease). When kidneys fail, the average life expectancy is just over two years and survival depends on costly and disabling dialysis or transplantation treatments.

State-of-the-art genomics and bioinformatics approaches are used to discover and characterize new molecular targets and pathways associated with apoptosis, transdifferentiation, and fibrogenesis in specialized renal cells exposed to diabetic and other stresses. TGF-beta signaling pathways and targets are a major theme because TGF-beta is a key mediator of these processes.

Model systems used include renal cell culture and mouse models of diabetic and non-diabetic progressive renal disease. A new genomic medicine program aims at identification and validation of molecular biomarkers that predict progressive kidney disease in humans.

Education

Nuremberg General Hospital, University of ErIangen-Nuremberg

Cabrini Medical Center

Massachusetts General Hospital and Harvard Medical School

National Cancer Institute, National Institutes of Health

MD, Friedrich-Alexander Universitat School of Medicine, Erlangen-Nurember

Publications

356

Publications

Selected Publications

Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits. Lauren E. Petty, Hung Hsin Chen, Elizabeth G. Frankel, Wanying Zhu, Carolina G. Downie, Mariaelisa Graff, Phillip Lin, Priya Sharma, Xinruo Zhang, Alyssa C. Scartozzi, Rashedeh Roshani, Joshua M. Landman, Michael Boehnke, Donald W. Bowden, John C. Chambers, Anubha Mahajan, Mark I. McCarthy, Maggie C.Y. Ng, Xueling Sim, Cassandra N. Spracklen, Weihua Zhang, Michael Preuss, Erwin P. Bottinger, Girish N. Nadkarni, Ruth J.F. Loos, Yii Der Ida Chen, Jingyi Tan, Eli Ipp, Pauline Genter, Leslie S. Emery, Tin Louie, Tamar Sofer, Adrienne M. Stilp, Kent D. Taylor, Anny H. Xiang, Thomas A. Buchanan, Kathryn Roll, Chuan Gao, Nicholette D. Palmer, Jill M. Norris, Lynne E. Wagenknecht, Darryl Nousome, Rohit Varma, Roberta McKean-Cowdin, Xiuqing Guo, Yang Hai, Willa Hsueh, Kevin Sandow, Esteban J. Parra, Susan K. Fried. Nature Communications

Defining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD. Vanessa Giselle Peschard, Rebecca Scherzer, Michelle M. Estrella, Mark J. Sarnak, Simon B. Ascher, James Lash, Joseph V. Bonventre, Jason H. Greenberg, Orlando M. Gutierrez, Jeffrey R. Schelling, Ronit Katz, Katharine L. Cheung, Emily B. Levitan, Sarah J. Schrauben, Mary Cushman, Titilayo O. Ilori, Chirag R. Parikh, Paul L. Kimmel, Panduranga S. Rao, Jonathan J. Taliercio, James Sondheimer, Rachel Shulman, Steven G. Coca, Jing Chen, Vasan S. Ramachandran, Joachim H. Ix, Michael G. Shlipak, Joseph Massaro, Clary Clish, Jeffrey Schelling, Tom Hostetter, Michelle Denburg, Susan Furth, Bradley Warady, Joseph Bonventre, Sushrut Waikar, Gearoid McMahon, Venkata Sabbisetti, Josef Coresh, Morgan Grams, Casey Rebholz, Alison Abraham, Adriene Tin, Jon Klein, Steven Coca, Bart S. Ferket, Girish N. Nadkarni, Eugene Rhee, Erwin Bottinger, Ilse Daehn. Clinical Journal of the American Society of Nephrology

Development and evaluation of Dona, a privacy-preserving donation platform for messaging data from WhatsApp, Facebook, and Instagram. Olya Hakobyan, Paul Julius Hillmann, Florian Martin, Erwin Böttinger, Hanna Drimalla. Behavior Research Methods

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Office Locations

Annenberg Building Floor 18 Room 16

1468 Madison Ave

New York, NY 10029

212-241-0800

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Bottinger has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Bottinger has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.