Eric A Sobie, PhD
img_Eric A Sobie
PROFESSOR | Pharmacological Sciences
Research Topics
Biophysics, Cardiovascular, Computational Biology, Electrophysiology, Mathematical Modeling of Biomedical Systems, Membrane Proteins/Channels, Signal Transduction
Multi-Disciplinary Training Area
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT)

Specific Research Interest:
Mechanisms underlying cardiac dysfunction and arrhythmias using physiological experiments coupled with mathematical modeling

Postdoctoral Fellows: Young-Seon Lee, Eva Polakova

Graduate and Medical Students: John Jones Molina, Megan Cummins, Ryan Devenyi, Pavan Dalal

Undergraduates and Visitors: Kathleen McGovern, Alessandro Giovannini, Allie Lopatkin

Research Personnel: Frank Fabris

The Sobie Laboratory combines mathematical modeling with state-of-the-art experimental techniques in order to improve our quantitative understanding of cardiac physiology.  We generate predictions using mathematical models, then test these predictions experimentally by measuring calcium and transmembrane voltage in heart cells.  This provides novel insight into the initiation of arrhythmias and dysfunction that occurs in disease states such as heart failure.  Specific research projects are described in more detail at our lab website.


Keywords: Biophysics, Calcium, Computer Simulation, Electrophysiology, Heart, Mathematical and Computational Biology, Systems Biology

Current Research Studies:
2010-2013: Novel computational approaches for understanding drug-induced arrhythmia. American Heart Association 10GRNT4170020.  The goal of this project is to use new computational methods to understand sources of inter-patient variability in arrhythmias caused by pharmacological agents.

2005-2014: Sarcoplasmic reticulum calcium leak and calcium instability in cardiac myocytes; National Institutes of Health R01 HL 076230; The goal of this project is to investigate, through experiments and simulation, sources of unstable, potentially arrhythmogenic calcium release in cardiac myocytes.

2007-2012Systems Biology Center in New York.  National Institutes of Health P50 GM071558-01; Dr. Sobie leads one of the projects in this multi-investigator grant.  We are developing methods for explicit multi-scale simulations of heart function.

BSE, Duke University

PhD, The Johns Hopkins University School of Medicine

Postdoctoral Fellowship, University of Maryland


Dr. Harold and Golden Lamport Research Award

Mount Sinai School of Medicine

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Sobie has not yet completed reporting of Industry relationships.

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