Dusan Bogunovic, PhD
img_Dusan Bogunovic
ADJUNCT PROFESSOR | Oncological Sciences
ADJUNCT PROFESSOR | Immunology & Immunotherapy
Research Topics
Cellular Immunity, Cytokines, Gene Regulation, Gene Therapy, Genetics, Genomics, Human Genetics and Genetic Disorders, Immune Antagonism, Immune Deficiency, Immunological Tolerance, Immunology, Immunosuppression, Infectious Disease, Inflammation, Interferon, Lymphocytes, Viruses and Virology
Multi-Disciplinary Training Area
Development Regeneration and Stem Cells [DRS], Microbiology [MIC]
Lab Website
https://labs.icahn.mssm.edu/bogunoviclab/
Human Immunogenetics
The Bogunovic lab focuses on the study of human immunogenetics. We aim to improve understanding of the human immune system by studying: 1) Individuals with rare auto-inflammatory syndromes. 2) Individuals with severe clinical presentations of infectious diseases. 3) Developing broad spectrum antiviral therapeutics. 4) Understanding immune system in Down syndrome. To dissect these phenotypes and develop therapeutics we use genomic, genetic, molecular biology, cellular biology, immunology and clinical tools. The hypothesis of the lab is that inter-individual variability in immune responses (in auto-inflammatory syndromes and infections) can also be explained by the immune genetic composition of the host. We aim to illuminate the elusive pathogenesis of these diseases, hoping to lay the foundation for a novel and paradigm-shifting approach to the rational design of both preventative medicine (vaccines and genetic counseling) and treatments beyond currently used antimicrobials.

PhD, New York University Medical School

Postdoctoral Fellow, The Rockefeller University

2019

Hirschl Scholar Award

Icahn School of Medicine at Mount Sinai

2018

Quickfire Challenge Winner

Johnson and Johnson

2017

Lamport Research Award

Icahn School of Medicine at Mount Sinai

2016

Young Investigator Award

American Society for Microbiology

2015

Milstein Award for Young Investigators

International Cytokine and Interferon Society

Publications

Selected Publications

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (Genome Medicine, (2023), 15, 1, (22), 10.1186/s13073-023-01173-8). Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andrés Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaïbi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarström, Nevin Hatipoğlu, Adem Karbuz, Sevgi Keles, Dusan Bogunovic, Yuval Itan, Nadjib Hammoudi. Genome Medicine

Correction to: Exclusive Characteristics of the p.E555K Dominant-Negative Variant in Autosomal Dominant E47 Deficiency (Journal of Clinical Immunology, (2024), 44, 7, (167), 10.1007/s10875-024-01758-x). Takanori Utsumi, Miyuki Tsumura, Masato Yashiro, Zenichiro Kato, Kosuke Noma, Fumiaki Sakura, Reiko Kagawa, Yoko Mizoguchi, Shuhei Karakawa, Hidenori Ohnishi, Charlotte Cunningham-Rundles, Peter D. Arkwright, Masao Kobayashi, Hirokazu Kanegane, Dusan Bogunovic, Bertrand Boisson, Jean Laurent Casanova, Takaki Asano, Satoshi Okada. Journal of Clinical Immunology

Racial Disparities in the Diagnosis of Inborn Errors of Immunity. Patrick O’Connell, O’Jay Stewart, Dusan Bogunovic. Journal of Clinical Immunology

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