David M Simpson, MD
img_David M Simpson
PROFESSOR | Neurology, Neuromuscular Diseases
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Research Topics
HIV/AIDS, Immune Deficiency, Infectious Disease, Motor Control, Neurology, Neuromuscular System, Neurophysiology, Neurotoxicology, Pain, Rehabilitation, Spinal Cord, Stroke, Viruses and Virology
Musician's Dystonia
Musician’s dystonia is a movement disorder that impacts the hands and arms. Approximately 1% of highly trained musicians face challenges associated with this disorder, which can be career-ending. Causes of Musician’s Dystonia are not well understood, and oral medications and rehabilitative measures rarely provide the results suffering musicians need. Dr. Simpson and his colleague Dr. Steven Frucht have begun a novel research project that provides patients with small doses of botulinum toxin (BoTN). Musicians from all over the world have participated in this study. The study has completed enrollment. The results are still being analyzed, but many patients have reported improvements that have allowed them to continue playing their instruments. Recently, one patient was able to begin playing the violin after giving it up for many years, and a drummer who was teaching has now returned to performing.
Botulinum Toxin A as a Treatment for Task-Dependent Upper Limb Tremor
Dr. Simpson co-designed a study to determine if botulinum (BoTN) can help individuals who suffer with task-dependent upper limb tremor. Patients who struggle with this disorder often have to abandon careers, in which they rely on their hands, (i.e. violinists, dentists, jewelers, surgeons). We are enrolling this exploratory pilot trial using botulinum toxin Type A in 20 patients with task-dependent upper limb tremor. The goal of this study is to gather information so that a larger multi-center study can be performed in the future.
Botulinum Toxin A as a Treatment for Upper and/or Lower Limb Spasticity
Dr. Simpson is currently enrolling two studies looking at the treatment of spasticity a condition of stiffness in the arm and/or leg because of a stroke or brain injury. The studies are looking at different doses with different types of botulinum toxin (BoTN). These studies are currently enrolling.
Ultrasound vs. E-Stimulation for Targeting Muscles
Drs. Simpson, Tse and Shin of the Mount Sinai Department of Neurology are leading a study in collaboration with a team led by Dr. Codrin Lungu at the National Institutes of Health. The study’s purpose is to compare two targeting methods- E-stimulation and ultrasound- for the treatment of muscles affected by spasticity and dystonia with botulinum toxin. The study is uniquely designed to investigate discomfort, timing and weakness.
Peripheral Neuropathy Research Registry (PNRR)
The goal of the Registry is to work to find blood markers to help scientists to develop drugs that either repair the nerves or reduce the pain caused by peripheral neuropathy. The registry includes any participant has neuropathy due to HIV disease, Diabetes, Chemical-Induced Neuropathy or Idiopathic Neuropathy.

MD, SUNY at Buffalo-School of Medicine & Biomedical Sciences

Residency, Neurology, New York Presbyterian Hospital-Weill Cornell Center

Fellowship, Clinical Neurophysiology, Massachusetts General Hospital


Am Board of Electrodiagnostic Medicine
American Board of Psychiatry and Neurology


America’s Top Doctors (Castle Connolly Medical)


Mitchell B Max Award in Neuropathic Pain

American Academy of Neurology


Best Doctors in New York, New York Magazine


Fellow of the Royal College of Physicians


Royal College of Physicians and Surgeons of Canada Service Award


Alpha Omega Alpha


James A. Gibson Anatomical Society


Selected Publications

Autoimmune conditions in the World Trade Center general responder cohort: A nested case-control and standardized incidence ratio analysis. Henry S. Sacks, Margaret Smirnoff, Deborah Carson, Michael L. Cooney, Moshe Z. Shapiro, Christopher J. Hahn, Christopher R. Dasaro, Cynthia Crowson, Ioannis Tassiulas, Robert P. Hirten, Benjamin L. Cohen, Richard S. Haber, Terry F. Davies, David M. Simpson, Michael A. Crane, Denise J. Harrison, Benjamin J. Luft, Jacqueline M. Moline, Iris G. Udasin, Andrew C. Todd, Nancy L. Sloan, Susan L. Teitelbaum. American Journal of Industrial Medicine

Correlates of HIV RNA concentrations in cerebrospinal fluid during antiretroviral therapy: a longitudinal cohort study. Alessandro Livelli, Florin Vaida, Ronald J. Ellis, Qing Ma, Micol Ferrara, David B. Clifford, Ann C. Collier, Benjamin B. Gelman, Christina M. Marra, Justin C. McArthur, J. Allen McCutchan, Susan Morgello, Ned Sacktor, David M. Simpson, Igor Grant, Scott L. Letendre, Ian Abramson, Muhammad T. Al-Lozi, Sarah L. Archibald, J. Hampton Atkinson, Brookie M. Best, Ann C. Collier, Clint Cushman, Matthew S. Dawson, Ronald J. Ellis, Christine Fennema-Notestine, Donald R. Franklin, Benjamin B. Gelman, Eleanor Head, Robert K. Heaton, Trudy Jones, Scott Letendre, Kenneth R. Maravilla, Thomas D. Marcotte, Christina M. Marra, Justin C. McArthur, J. Allen McCutchan, Letty Mintz, Thomas P. Naidich, David M. Simpson, David M. Smith, Keith C. Stegbauer, Cheuk Y. Tang, Mengesha Teshome. The Lancet HIV

Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia. Pariya L. Fazeli, David J. Moore, Donald R. Franklin, Anya Umlauf, Robert K. Heaton, Ann C. Collier, Christina M. Marra, David B. Clifford, Benjamin B. Gelman, Ned C. Sacktor, Susan Morgello, David M. Simpson, John A. McCutchan, Igor Grant, Scott L. Letendre, Igor Grant, Scott L. Letendre, Ronald J. Ellis, Thomas D. Marcotte, Donald Franklin, Ronald J. Ellis, J. Allen McCutchan, Scott Letendre, Davey M. Smith, Robert K. Heaton, J. Hampton Atkinson, Christine Fennema-Notestine, Michael J. Taylor, Rebecca Theilmann, Anthony C. Gamst, Clint Cushman, Ian Abramson, Florin Vaida, Reena Deutsch, Justin McArthur, Vincent Rogalski, Susan Morgello, David Simpson, Letty Mintz, J. Allen McCutchan, Kaori Phillips, Ann Collier, Christina Marra, Trudy Jones, Benjamin Gelman, Eleanor Head, Muhammad Al-Lozi, Mengesha Teshome. Current HIV Research

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Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Simpson during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.


  • Allergan, Inc.
  • Grünenthal Group
  • Averitas
  • ArgenX
  • Alexion Pharmaceuticals, Inc.
  • Ipsen

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.