Brian Kopell - Neurosurgery | Mount Sinai

Biography

Specialties

Neurosurgery

Research

Electrophysiological Biomarkers to Optimize Deep Brain Stimulation for Depression

The Icahn School of Medicine at Mount Sinai is running a single-center experimental trial of deep brain stimulation (DBS) to the subcallosal cingulate region (Area 25) for treatment resistant depression (TRD). The goal of this study is to refine and optimize this treatment approach using a newly available neuromodulation system (the Medtronic Summit RC+S) that allows brain activity during ongoing therapeutic DBS to be recorded from the brain in real-time. This study will further define brain readouts that track depression recovery, providing novel strategies to monitor and guide treatment and device programming decisions in patients receiving DBS for TRD.

Participating Mount Sinai Programs:

To enroll in the study contact Emma Meyer at 212-241-6539 or dac@mssm.edu.
For more information visit Mount Sinai Clinical Trials.

Cortical Stimulation for Tinnitus
Cortical and Deep Brain Stimulation for Depression and Obsessive Compulsive Disorder
Intraoperative Image-Guidance for Deep Brain Stimulation

Education

MD, New York University School of Medicine

Internship, Surgery (General Surgery), NYU Medical Center

Residency, Neurosurgery, NYU Medical Center

Fellowship, Neurosurgery, Cleveland Clinic Foundation

Certifications

American Board of Neurological Surgery

Honors & Awards

2015-2019

Top Doctors - New York Metro Area

Castle Connolly

Publications

111

Publications

Selected Publications

Towards accredited clinical training in brain stimulation: Proceedings from the brain stimulation subspecialty summits. Shan H. Siddiqi, Leo Chen, Nicholas T. Trapp, Noreen Bukhari-Parlakturk, Joseph J. Taylor, Aaron D. Boes, Joshua C. Brown, Tracy Barbour, Joan A. Camprodon, Michael D. Fox, Brian H. Kopell, Carlene MacMillan, Alfonso Fasano, Robert S. Fisher, Ziad Nahas, Gonzalo J. Revuelta, Patricio Riva-Posse, John D. Rolston, Katherine Scangos, Mouhsin M. Shafi, Andrew H. Smith, Joshua Wong, Casey H. Halpern, Helen S. Mayberg, Nolan R. Williams. Brain Stimulation

Co-stimulating the left vmPFC compensates for apathy after levodopa withdrawal in Parkinson's patients with STN DBS. Jip de Bruin, Ki Sueng Choi, Helen S. Mayberg, Joohi Jimenez-Shahed, Christina A. Palmese, Juna Khang, Ha Neul Song, Brian H. Kopell, Martijn Figee. Parkinsonism and Related Disorders

Author Correction: Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system (Nature Biotechnology, (2024), 10.1038/s41587-024-02487-7). Chang Wang, Siyu Wang, Yonger Xue, Yichen Zhong, Haoyuan Li, Xucheng Hou, Diana D. Kang, Zhengwei Liu, Meng Tian, Leiming Wang, Dinglingge Cao, Yang Yu, Jayce Liu, Xiaolin Cheng, Tamara Markovic, Alice Hashemi, Brian H. Kopell, Alexander W. Charney, Eric J. Nestler, Yizhou Dong. Nature Biotechnology

View All Publications

Video

Deep Brain Stimulation Surgery to treat Parkinson's Disease at Mount Sinai Hospital

Office Locations

Mount Sinai West

1000 Tenth Avenue, Tenth Floor

New York, NY 10019

212-523-8340

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Kopell during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

Abbott Neuromodulation
Turing Medical
Medtronic, Inc

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Kopell during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

Abbott Neuromodulation
Turing Medical
Medtronic, Inc

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.