Find Faculty

Brian Kopell, MD

img_Brian Kopell
PROFESSOR | Neurosurgery
PROFESSOR | Psychiatry
PROFESSOR | Neurology
PROFESSOR | Neuroscience
212-523-8340
email
Are you a patient?
View my
Provider Profile
Specialties
Neurosurgery
Electrophysiological Biomarkers to Optimize Deep Brain Stimulation for Depression
The Icahn School of Medicine at Mount Sinai is running a single-center experimental trial of deep brain stimulation (DBS) to the subcallosal cingulate region (Area 25) for treatment resistant depression (TRD). The goal of this study is to refine and optimize this treatment approach using a newly available neuromodulation system (the Medtronic Summit RC+S) that allows brain activity during ongoing therapeutic DBS to be recorded from the brain in real-time. This study will further define brain readouts that track depression recovery, providing novel strategies to monitor and guide treatment and device programming decisions in patients receiving DBS for TRD.
   
Participating Mount Sinai Programs:
To enroll in the study contact Emma Meyer at 212-241-6539 or dac@mssm.edu.
For more information visit Mount Sinai Clinical Trials.


Cortical Stimulation for Tinnitus
Cortical and Deep Brain Stimulation for Depression and Obsessive Compulsive Disorder
Intraoperative Image-Guidance for Deep Brain Stimulation

MD, New York University School of Medicine

Internship, Surgery (General Surgery), NYU Medical Center

Residency, Neurosurgery, NYU Medical Center

Fellowship, Neurosurgery, Cleveland Clinic Foundation

Certifications

American Board of Neurological Surgery

2015-2019

Top Doctors - New York Metro Area

Castle Connolly

129
Publications

Selected Publications

Corrigendum to “Revisiting subcallosal cingulate deep brain stimulation for depression: Long-term safety and effectiveness outcomes from a pooled analysis of 172 implanted patients” [Brain Stimul 18 (2025) 1632-1640, (S1935861X25003109), (10.1016/j.brs.2025.08.017)]. Lyndahl M. Himes, Helen S. Mayberg, Mustafa M. Husain, Paul E. Holtzheimer, Andres M. Lozano, Sidney H. Kennedy, Robert E. Gross, Brian H. Kopell, Martijn Figee, Konstantin V. Slavin, Julie G. Pilitsis, Joseph S. Neimat, Clement Hamani, Nader Pouratian, Peter Giacobbe, Alon Y. Mogilner, Keyoumars Ashkan, Devyani Nanduri, Binith J. Cheeran, Yagna J. Pathak, Patricio Riva-Posse. Brain Stimulation

A transcriptional program associated with neurotransmission in the living human brain. Alexander W. Charney, Lora E. Liharska, Eric Vornholt, Alissa Valentine, Anina Lund, Alice Hashemi, Ryan C. Thompson, Terry Lohrenz, Jessica S. Johnson, Nicole Bussola, Esther Cheng, You Jeong Park, Salman Qasim, Alisha Aristel, Lillian Wilkins, Kimia Ziafat, Hannah Silk, Lisa M. Linares, Brendan Sullivan, Claudia Feng, Seth R. Batten, Dan Bang, Leonardo S. Barbosa, Thomas Twomey, Jason P. White, Marina Vannucci, Beniamino Hadj-Amar, Emily Moya, Martijn Figee, Girish N. Nadkarni, Michael S. Breen, Kenneth T. Kishida, Joseph Scarpa, Eric E. Schadt, Ignacio Saez, P. Read Montague, Noam D. Beckmann, Brian H. Kopell. Molecular Psychiatry

Sustained activity of human substantia nigra neurons reflect prior rewards. Zarghona Imtiaz, Ayaka Kato, Brian H. Kopell, Salman E. Qasim, Arianna Neal Davis, Lizbeth Nunez Martinez, Matthew Heflin, Kaustubh Kulkarni, Amr Morsi, Alexander W. Charney, Xiaosi Gu, Ignacio Saez. iScience

View All Publications

To Dream Again
Deep Brain Stimulation Surgery to treat Parkinson's Disease at Mount Sinai Hospital

Mount Sinai West

1000 Tenth Avenue, Tenth Floor

New York, NY 10019

212-523-8340

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Kopell during 2025 and/or 2026. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

  • Abbott Neuromodulation
  • Turing Medical

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.