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Anne Schaefer, MD, PhD
img_Anne Schaefer
PROFESSOR | Neuroscience
PROFESSOR | Psychiatry
PROFESSOR | Immunology & Immunotherapy
212-659-5987
email
Research Topics
Basal Ganglia, Brain, Chromatin, Epigenetics, Genetics, Human Genetics and Genetic Disorders, Knockout Mice, Locomotion, Mental Retardation, Multiple Sclerosis
Multi-Disciplinary Training Area
Neuroscience [NEU]
Our research focuses on identifying the epigenetic basis of neurodegenerative and psychiatric disorders. We study how miRNAs and histone modifying enzymes contribute to the establishment and maintenance of neuronal identity and specialized functions. We are particularly interested in understanding the epigenetic mechanisms of cellular plasticity and its role in regulation of microglia-neuron communication in health and disease. One of the major focuses of our research lies in the development of animal models of human neurological disease associated with abnormal function of epigenetic regulators of different types. Using pioneering technologies including cell type specific analysis of mRNAs, miRNAs and chromatin modifications in neurons in vivo, our research aims at understanding the mechanism of neurological disorders and at their potential treatment by targeting the neuronal epigenome.

MD, Johannes Gutenberg University

MD, Charité University

Postdoc, The Rockefeller University

2018

Inaugural NINDS Landis Award for Outstanding Mentorship

NIH NINDS

2018

Inventor of the Year 2018 Award

Mount Sinai

2015

Harold and Golden Lamport Research Award

Mount Sinai

2014

Technology Development Fund Award

Mount Sinai Innovation

2014

Cure Challenge Award

Cure Challenge

2014

Kavli Frontiers in Science Fellow

The National Academy of Science

2012

Chrissy Rossi Investigator

Chrissy Rossi

2012

Research Award

Seaver Autism Center

2012

NIH Director’s New Innovator Award

NIH

2011

NARSAD Young Investigator Award

NARSAD

2006

Research Fellowship

German Research Foundation DFG

2005

Hans-Hench Award 2005

German Society for Immunology, Germany

2004

Summa cum lauden

Charité University Berlin

2003

Research Award

Keystone Scholar Travel Award

2001

USA Research Scholarship

The German National Academic Foundation

1999

Scholarship

German National Merit Foundation

50
Publications

Selected Publications

ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling. Flavia Scoyni, Valeriia Sitnikova, Luca Giudice, Paula Korhonen, Davide M. Trevisan, Ana Hernandez de Sande, Mireia Gomez-Budia, Raisa Giniatullina, Irene F. Ugidos, Hiramani Dhungana, Cristiana Pistono, Nea Korvenlaita, Nelli Noora Välimäki, Salla M. Kangas, Anniina E. Hiltunen, Emma Gribchenko, Minna U. Kaikkonen-Määttä, Jari Koistinaho, Seppo Ylä-Herttuala, Reetta Hinttala, Morten T. Venø, Junyi Su, Markus Stoffel, Anne Schaefer, Nikolaus Rajewsky, Jørgen Kjems, Mary P. LaPierre, Monika Piwecka, Jukka Jolkkonen, Rashid Giniatullin, Thomas B. Hansen, Tarja Malm. Cell Reports

A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation. William T. Ralvenius, Alison E. Mungenast, Hannah Woolf, Margaret M. Huston, Tyler Z. Gillingham, Stephen K. Godin, Jay Penney, Hugh P. Cam, Fan Gao, Celia G. Fernandez, Barbara Czako, Yaima Lightfoot, William J. Ray, Adrian Beckmann, Alison M. Goate, Edoardo Marcora, Carmen Romero-Molina, Pinar Ayata, Anne Schaefer, Elizabeta Gjoneska, Li Huei Tsai. Journal of Experimental Medicine

A comparative analysis of microglial inducible Cre lines. Travis E. Faust, Philip A. Feinberg, Ciara O'Connor, Riki Kawaguchi, Andrew Chan, Hayley Strasburger, Maximilian Frosch, Margaret A. Boyle, Takahiro Masuda, Lukas Amann, Klaus Peter Knobeloch, Marco Prinz, Anne Schaefer, Dorothy P. Schafer. Cell Reports

View All Publications

Icahn (East) Building Floor 10 Room 10-70A Office

1425 Madison Ave

New York, NY 10029

212-659-5987

Icahn (East) Building Floor 10 Room 10-76 Lab

1425 Madison Ave

New York, NY 10029

212-659-5577

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Schaefer during 2023 and/or 2024. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Board Service

  • Max Planck Institute

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.