Anne Bowcock, PhD
img_Anne Bowcock
PROFESSOR | Dermatology
PROFESSOR | Oncological Sciences
PROFESSOR | Genetics and Genomic Sciences
Research Topics
Angiogenesis, Anti-Tumor Therapy, Antigen Presentation, Apoptosis/Cell Death, Autoimmunity, Bioinformatics, Bone Biology, Breast Cancer, Cancer, Cancer Genetics, Cartilage Biology, Cellular Differentiation, Cellular Immunity, Chemokines, Chromatin, Computational Biology, Dendritic Cells, Differentiation, Eczema, Endothelial Cells, Epigenetics, Epigenomics, Epithelial Cells, Gap Junctions, Genetics, Genomics, Human Genetics and Genetic Disorders, Inflammation, Interferon, Knockout Mice, Metastasis, Microarray, Ophthalmology, Post-Transcriptional Processing, RNA, RNA Splicing & Processing, Retina, Retrovirus, Skin Cancer, T Cells, Tolerance, Transgenic Mice, Translation, Tumor Suppressor Genes, Tumorigenesis, Wound Healing
Multi-Disciplinary Training Area
Cancer Biology [CAB], Genetics and Genomic Sciences [GGS]
We investigate the genetics and genomics of psoriasis and psoriatic arthritis and ways of combatting their effects. We have profiled the psoriasis transcriptome and identified the majority of small RNAs (microRNAs and others) operating in healthy and diseased skin. We continue to investigate the roles of these small RNAs and their cellular targets. We also identified a gene mutated in a familial form of psoriasis and psoriatic arthritis (CARD14) and determined the functional consequence of its psoriasis causing mutations. We are now generating murine models of the mutations to help in understanding how CARD14 mutations lead to disease. We are also using this mouse model to examine the effects of novel therapeutics for psoriasis and psoriatic arthritis. To identify additional common and rare variants predisposing to psoriasis we are exome sequencing unrelated patients, and are also searching for the common (GWAS identified) risk factors through genomic/epigenomic analyses of key cell types involved in disease pathogenesis. With respect to cancer, we are investigating the molecular basis of a number of adult cancers including uveal melanoma, acral melanoma, mesothelioma and thymic epithelial cancers. This involves exome and genome sequencing, RNA sequencing and a search for novel gene fusions, and an investigation of tumor heterogeneity and evolution. We were the first to identify the major genetic drivers of uveal melanoma (BAP1 and SF3B1) and are currently investigating their role in tumorigenesis and metastasis.

Visit the Bowcock Laboratory

PhD, University of the Witwatersand

Post-Doc, Stanford University


American Skin Association 2005 Psoriasis Achievement Award


Medical Research Council (South Africa) Award


British Petroleum Research Studentship


Julius Robson Postgraduate Scholarship


Selected Publications

Correlation between BAP1 Localization, Driver Mutations, and Patient Survival in Uveal Melanoma. Yasemin C. Cole, Yu Zhi Zhang, Beatrice Gallo, Adam P. Januszewski, Anca Nastase, David J. Essex, Caroline M.H. Thaung, Victoria M.L. Cohen, Mandeep S. Sagoo, Anne M. Bowcock. Cancers

Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa. Samuel Terkper Ahuno, Anna Lisa Doebley, Thomas U. Ahearn, Joel Yarney, Nicholas Titiloye, Nancy Hamel, Ernest Adjei, Joe Nat Clegg-Lamptey, Lawrence Edusei, Baffour Awuah, Xiaoyu Song, Verna Vanderpuye, Mustapha Abubakar, Maire Duggan, Daniel G. Stover, Kofi Nyarko, John M.S. Bartlett, Francis Aitpillah, Daniel Ansong, Kevin L. Gardner, Felix Andy Boateng, Anne M. Bowcock, Carlos Caldas, William D. Foulkes, Seth Wiafe, Beatrice Wiafe-Addai, Montserrat Garcia-Closas, Alexander Kwarteng, Gavin Ha, Jonine D. Figueroa, Paz Polak, Robertson Adjei, Lucy Afriyie, Anthony Adjei, Florence Dedey, Victoria Okyne, Naomi Ohene Oti, Evelyn Tay, Adu-Aryee, Angela Kenu, Obed Ekpedzor, Marion Alcpaloo, Isaac Boakye, Bernard Arhin, Emmanuel Assimah, Samuel Ka-Chungu, Joseph Oppong, Ernest Osei-Bonsu, Margaret Frempong, Emma Brew Abaidoo. npj Precision Oncology

Clinicopathological features and associations in a series of South African acral melanomas. Bianca Tod, Willie Visser, Johann de Wet, Maritha Kotze, Anne Bowcock, Birhanu Ayele, Michael McCaul, Johann Schneider. Pigment Cell and Melanoma Research

View All Publications

Cancer Precision Medicine Retreat -- Session 1: Anne Bowcock

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Bowcock during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Royalty Payments:

  • Castle Biosciences Inc

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.