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Aneel K Aggarwal, PhD
img_Aneel K Aggarwal
PROFESSOR | Pharmacological Sciences
PROFESSOR | Oncological Sciences
212-659-8650
email
Research Topics
DNA Repair, DNA Replication, Structural Biology, Transcription Factors, Translation
Multi-Disciplinary Training Area
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT), Genetics and Genomic Sciences [GGS]
Protein-nucleic acid interactions

We use a variety of structural tools to uncover how enzymes, and transcription and translation regulators interact with nucleic acids to affect cellular development and disease outcome. We study how such proteins locate, bind, and move on their DNA or RNA sites, and, then use that knowledge to create enzymes with new specificities and obtain a molecular understanding for how genes are regulated. We are also interested in learning how cells cope with the effects of DNA damage. In particular, we investigate how a set of specialized DNA polymerases can bypass DNA damage during replication and how mutations in them can lead to cancer.


Laboratory website: http://www.protdnarna.org

PhD, Kings College, University of London

Harvard University

2012

Dean’s Award for Excellence in Basic Science Research

2010

Faculty Council Award for Academic Excellence

2007

Mount Sinai Professor in Structural Biology (Endowed Chair)

1995

The Doctor Harold and Golden Lamport Award for Excellence in Basic Science Research

1990

Irma T. Hirschl Career Scientist Award

1990

Basil O'Connor Starter Scholar Research Award

1985

The North Atlantic Treaty Organization (NATO) Research Fellowship

1985

EMBO Long-term Fellowship (Declined)

1981

Science and Engineering Research Council (SERC) of Great Britain Studentship

170
Publications

Selected Publications

Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation. Richard Quintana-Feliciano, Jithesh Kottur, Mi Ni, Rikhia Ghosh, Leslie Salas-Estrada, Goran Ahlsen, Olga Rechkoblit, Lawrence Shapiro, Marta Filizola, Gang Fang, Aneel K. Aggarwal. Nature Communications

Nucleic acid mediated activation of a short prokaryotic Argonaute immune system. Jithesh Kottur, Radhika Malik, Aneel K. Aggarwal. Nature Communications

Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro. Duc Duy Vu, Alessio Bonucci, Manon Brenière, Metztli Cisneros-Aguirre, Philippe Pelupessy, Ziqing Wang, Ludovic Carlier, Guillaume Bouvignies, Patricia Cortes, Aneel K. Aggarwal, Martin Blackledge, Zoher Gueroui, Valérie Belle, Jeremy M. Stark, Mauro Modesti, Fabien Ferrage. Nature Structural and Molecular Biology

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Icahn (East) Building Floor 16 Room 16-20C

1425 Madison Ave

New York, NY 10029

212-659-8650

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Aggarwal has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.