Aneel K Aggarwal, PhD
img_Aneel K Aggarwal
PROFESSOR | Pharmacological Sciences
PROFESSOR | Oncological Sciences
Research Topics
DNA Repair, DNA Replication, Structural Biology, Transcription Factors, Translation
Multi-Disciplinary Training Area
Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT), Genetics and Genomic Sciences [GGS]
Protein-nucleic acid interactions

We use a variety of structural tools to uncover how enzymes, and transcription and translation regulators interact with nucleic acids to affect cellular development and disease outcome. We study how such proteins locate, bind, and move on their DNA or RNA sites, and, then use that knowledge to create enzymes with new specificities and obtain a molecular understanding for how genes are regulated. We are also interested in learning how cells cope with the effects of DNA damage. In particular, we investigate how a set of specialized DNA polymerases can bypass DNA damage during replication and how mutations in them can lead to cancer.

Laboratory website:

PhD, Kings College, University of London

Harvard University


Dean’s Award for Excellence in Basic Science Research


Faculty Council Award for Academic Excellence


Mount Sinai Professor in Structural Biology (Endowed Chair)


The Doctor Harold and Golden Lamport Award for Excellence in Basic Science Research


Irma T. Hirschl Career Scientist Award


Basil O'Connor Starter Scholar Research Award


The North Atlantic Treaty Organization (NATO) Research Fellowship


EMBO Long-term Fellowship (Declined)


Science and Engineering Research Council (SERC) of Great Britain Studentship

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Aggarwal has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.