Research in the Bond Lab is motivated by the great need for effective treatments for brain disorders and the promise of stem cells as a target for medical interventions. Neural stem cells possess the incredible capacity to generate new cells over long periods of time, but we do not understand how they are regulated inside the brain. Our lab works to uncover the endogenous programs that regulate stem cell capacity across the lifespan in vivo so that we can successfully target the brain’s innate plasticity for therapeutic purposes. The Bond Lab is focused on understanding how interactions between neural stem cells and the surrounding niche environment influence the capacity for neural plasticity across the lifespan. The lab uses single-cell omics, lineage tracing, viral and CRISPR genetic manipulations, and time-lapse imaging to study neural stem cells in the mammalian hippocampus. The goal of the lab’s research is to identify therapeutic interventions that promote and preserve the brain’s endogenous regenerative capacity.