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Alison M Goate, DPhil
img_Alison M Goate
PROFESSOR & CHAIR | Genetics and Genomic Sciences
PROFESSOR | Neuroscience
PROFESSOR | Neurology
212-659-5672
email
Research Topics
Alzheimer's Disease, Gene editing, Genomics, Neurobiology, Neuroscience
Multi-Disciplinary Training Area
Genetics and Genomic Sciences [GGS], Immunology [IMM], Neuroscience [NEU]
Research in our laboratory focuses on dementia (Alzheimer's disease & frontotemporal dementia) and addiction (alcohol dependence). In each of these projects our goal is to understand the molecular basis of disease in order to identify novel targets for therapeutic development. We use genetic and genomic approaches to identify susceptibility alleles, this work includes integration of multiple levels of OMICs data with genetic data from genome wide association studies and whole genome/exome sequencing in families multiply affected by disease and in case control cohorts. Through these studies we have demonstrated an enrichment of AD risk variants in microglial enhancers. Interestingly variants within the SPI1 (PU.1) locus, a gene which regulates myeloid cell differentiation, influence risk for AD and for alcoholism, demonstrating the importance of neuroimmune communication in both disorders. We are currently pursuing these observations in cell and animal models with the goal of developing PU.1 inhibitors for treatment of AD. In combination with our genetic studies we use induced pluripotent stem cells in vitro and in vivo to study the mechanisms of risk underlying the AD risk genes. To date we have performed functional studies of APOE, SPI1 and MS4A4A/6A in induced microglia. We also have an extensive program studying the functional consequences of MAPT mutations and haplotypes in tauopathies such as PSP and FTD, using iPSC-derived neurons and organoids.

BSc, Hons, University of Bristol

DPhil, Linacre College, University of Oxford

Postdoctoral Research Fellow, Eleanor Roosevelt Institute for Cancer Research

Postdoctoral Research Fellow, Institute of Neurology, University College London

Postdoctoral Research Fellow, St. Mary's Hospital Medical School, Imperial College

2023

Piepenbrock-DZNE Prize for Neurodegenerative disease research

Piepenbrock-DZNE

2022

Rainwater Prize for Innovation in Neurodegeneration

Rainwater Charitable Foundation

2022

Best Female Scientists in the World

Research.com

2020

Keynote Address, Tau 2020, Washington D.C

2019

Methusalem Lecture, VIB-KU, Center for Brain & Disease Research, Leuven

2019

Plenary Lecture, 6th Venusberg Meeting on Neuroinflammation (5/9/19)

2019

DeArmond Lecture American Association of Neuropathologists, Atlanta

2019

F.E. Bennett Memorial Lectureship, American Neurological Association, St. Louis

2018

Affiliated Faculty, New York Genome Center (NYGC)

2016

Elected member of the National Academy of Medicine

2015

Willard T.C. Johnson Research Professor of Neurogenetics (ISMMS)

2015

Khalid Iqbal Lifetime Acheivement Award, Alzheimer’s Association

2015

Blas Frangione Foundation Lecture

NYU

2015

Willard T.C. Johnson Research Professor of Neurogenetics, Professor of Neuroscience, Professor of Neurology, Professor of Genetics & Genomic Sciences

Icahn School of Medicine at Mount Sinai

2015

Director, Ronald Loeb Center for Alzhemier’s Disease

Icahn School of Medicine at Mount Sinai

2015

Associate Director, Alzheimer’s Disease Research Center

Icahn School of Medicine at Mount Sinai

2012

Elected Fellow, American Association for the Advancement of Science

2005

Carl & Gerty Cori Faculty Achievement Award

1994

Senior Investigator Award, Metropolitan Life Foundation

1994

St. Louis Academy of Science Innovation Award

1993

Potamkin Prize for Alzheimer's disease research

1993

Zenith Award, Alzheimer's Association

1989-

Royal Society University Research Fellow

728
Publications

Selected Publications

Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease. Phoebe Valdes, Andrew B. Caldwell, Qing Liu, Michael Q. Fitzgerald, Srinivasan Ramachandran, Celeste M. Karch, Xiong Xu, Jinbin Xu, Chengjie Xiong, Elise Weamer, Qing Wang, Peter Wang, Jonathan Vöglein, Sarah Thompson, Kevin Taddei, Sochenda Stephens, Hamid Sohrabi, Beth Snitz, Lori Smith, Jennifer Smith, Wendy Sigurdson, Hiroyuki Shimada, Kristine Shady, Nicholas T. Seyfried, Michio Senda, Peter Schofield, Stephen Salloway, John Ringman, Alan Renton, Oliver Preische, Lingyan Ping, Richard Perrin, Riddhi Patira, Antoinette O’Connor, Ulricke Obermüller, Brigitte Nuscher, Joanne Norton, James Noble, Yoshiki Niimi, Katie Neimeyer, Akemi Nagamatsu, Neelesh Nadkarni, Cath Mummery, James Mountz, John Morris, Estrella Morenas-Rodriguez, Arlene Mejia, Eric McDade, Austin McCullough, Alison Goate. Alzheimer's Research and Therapy

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus. Alessandro Matera, Anne Claire Compagnion, Chiara Pedicone, Janssen M. Kotah, Andranik Ivanov, Katia Monsorno, Gwenaël Labouèbe, Loredana Leggio, Marta Pereira-Iglesias, Dieter Beule, Virginie Mansuy-Aubert, Tim L. Williams, Nunzio Iraci, Amanda Sierra, Samuele G. Marro, Alison M. Goate, Bart J.L. Eggen, William G. Kerr, Rosa C. Paolicelli. Immunity

Correction to: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction (Nature Neuroscience, (2021), 24, 10, (1367-1376), 10.1038/s41593-021-00908-3). Richard Karlsson Linnér, Travis T. Mallard, Peter B. Barr, Sandra Sanchez-Roige, James W. Madole, Morgan N. Driver, Holly E. Poore, Ronald de Vlaming, Andrew D. Grotzinger, Jorim J. Tielbeek, Emma C. Johnson, Mengzhen Liu, Sara Brin Rosenthal, Trey Ideker, Hang Zhou, Rachel L. Kember, Joëlle A. Pasman, Karin J.H. Verweij, Dajiang J. Liu, Scott Vrieze, Abbas Parsian, Hemin Chin, Peter B. Barr, Fazil Aliev, Scott Saccone, Vivia V. McCutcheon, Andrey P. Anokhin, Michael J. Chao, Gayathri Pandey, Sivan Kinreich, Jian Zhang, David B. Chorlian, Grace Chan, Laura Acion, Spencer Lourens, Martin H. Plawecki, Sean J. O’Connor, Dongbing Lai, Xiaoling Xuei, Leah Wetherill, Lance Bauer, Denise M. Scott, Paul Slesinger, Manav Kapoor, Allison Goate, Jessica E. Salvatore, Danielle M. Dick, Laura Almasy, Ronald P. Hart, Andrew Brooks. Nature Neuroscience

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212-659-5672

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Below are financial relationships with industry reported by Dr. Goate during 2024 and/or 2025. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting or Other Professional Services Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

  • Merck & Co., Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.