Alison M Goate, DPhil
img_Alison M Goate
PROFESSOR & CHAIR | Genetics and Genomic Sciences
PROFESSOR | Neuroscience
PROFESSOR | Neurology
Multi-Disciplinary Training Area
Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
Research in our laboratory focuses on dementia (Alzheimer's disease & frontotemporal dementia) and addiction (alcohol dependence). In each of these projects our goal is to understand the molecular basis of disease in order to identify novel targets for therapeutic development. We use genetic and genomic approaches to identify susceptibility alleles, this work includes integration of multiple levels of OMICs data with genetic data from genome wide association studies and whole genome/exome sequencing in families multiply affected by disease and in case control cohorts. Through these studies we have demonstrated an enrichment of AD risk variants in microglial enhancers. Interestingly variants within the SPI1 (PU.1) locus, a gene which regulates myeloid cell differentiation, influence risk for AD and for alcoholism, demonstrating the importance of neuroimmune communication in both disorders. We are currently pursuing these observations in cell and animal models with the goal of developing PU.1 inhibitors for treatment of AD. In combination with our genetic studies we use induced pluripotent stem cells in vitro and in vivo to study the mechanisms of risk underlying the AD risk genes. To date we have performed functional studies of APOE, SPI1 and MS4A4A/6A in induced microglia. We also have an extensive program studying the functional consequences of MAPT mutations and haplotypes in tauopathies such as PSP and FTD, using iPSC-derived neurons and organoids.

BSc, Hons, University of Bristol

DPhil, Linacre College, University of Oxford

Postdoctoral Research Fellow, Eleanor Roosevelt Institute for Cancer Research

Postdoctoral Research Fellow, Institute of Neurology, University College London

Postdoctoral Research Fellow, St. Mary's Hospital Medical School, Imperial College


Keynote Address, Tau 2020, Washington D.C


Methusalem Lecture, VIB-KU, Center for Brain & Disease Research, Leuven


Plenary Lecture, 6th Venusberg Meeting on Neuroinflammation (5/9/19)


DeArmond Lecture American Association of Neuropathologists, Atlanta


F.E. Bennett Memorial Lectureship, American Neurological Association, St. Louis


Affiliated Faculty, New York Genome Center (NYGC)


Elected member of the National Academy of Medicine


Willard T.C. Johnson Research Professor of Neurogenetics (ISMMS)


Khalid Iqbal Lifetime Acheivement Award, Alzheimer’s Association


Blas Frangione Foundation Lecture



Willard T.C. Johnson Research Professor of Neurogenetics, Professor of Neuroscience, Professor of Neurology, Professor of Genetics & Genomic Sciences

Icahn School of Medicine at Mount Sinai


Director, Ronald Loeb Center for Alzhemier’s Disease

Icahn School of Medicine at Mount Sinai


Associate Director, Alzheimer’s Disease Research Center

Icahn School of Medicine at Mount Sinai


Elected Fellow, American Association for the Advancement of Science


Carl & Gerty Cori Faculty Achievement Award


Senior Investigator Award, Metropolitan Life Foundation


St. Louis Academy of Science Innovation Award


Potamkin Prize for Alzheimer's disease research


Zenith Award, Alzheimer's Association


Royal Society University Research Fellow


Selected Publications

Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease. Muhammad Ali, Derek B. Archer, Priyanka Gorijala, Daniel Western, Jigyasha Timsina, Maria V. Fernández, Ting Chen Wang, Claudia L. Satizabal, Qiong Yang, Alexa S. Beiser, Ruiqi Wang, Gengsheng Chen, Brian Gordon, Tammie L.S. Benzinger, Chengjie Xiong, John C. Morris, Randall J. Bateman, Celeste M. Karch, Eric McDade, Alison Goate, Sudha Seshadri, Richard P. Mayeux, Reisa A. Sperling, Rachel F. Buckley, Keith A. Johnson, Hong Hee Won, Sang Hyuk Jung, Hang Rai Kim, Sang Won Seo, Hee Jin Kim, Elizabeth Mormino, Simon M. Laws, Kang Hsien Fan, M. Ilyas Kamboh, Prashanthi Vemuri, Vijay K. Ramanan, Hyun Sik Yang, Allen Wenzel, Hema Sekhar Reddy Rajula, Aniket Mishra, Carole Dufouil, Stephanie Debette, Oscar L. Lopez, Steven T. DeKosky, Feifei Tao, Michael W. Nagle, Timothy J. Hohman, Yun Ju Sung, Logan Dumitrescu, Carlos Cruchaga. Acta neuropathologica communications

Sex specific molecular networks and key drivers of Alzheimer’s disease. Lei Guo, Jiqing Cao, Jianwei Hou, Yonghe Li, Min Huang, Li Zhu, Larry Zhang, Yeji Lee, Mariana Lemos Duarte, Xianxiao Zhou, Minghui Wang, Chia Chen Liu, Yuka Martens, Michael Chao, Alison Goate, Guojun Bu, Vahram Haroutunian, Dongming Cai, Bin Zhang. Molecular Neurodegeneration

Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Logan Brase, Shih Feng You, Ricardo D’Oliveira Albanus, Jorge L. Del-Aguila, Yaoyi Dai, Brenna C. Novotny, Carolina Soriano-Tarraga, Taitea Dykstra, Maria Victoria Fernandez, John P. Budde, Kristy Bergmann, John C. Morris, Randall J. Bateman, Richard J. Perrin, Eric McDade, Chengjie Xiong, Alison M. Goate, Martin Farlow, Greg T. Sutherland, Jonathan Kipnis, Celeste M. Karch, Bruno A. Benitez, Oscar Harari. Nature Communications

View All Publications

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Goate during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose

  • Washington University, St. Louis
  • Texas Methodist Hosptial
  • Mass General Brigham
  • AbbVie Inc.

Other activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership

  • Washington University, St. Louis
  • Columbia University
  • Indiana University School of Medicine
  • UK Dementia Research Institute
  • University of Pennsylvania

Royalty Payments:

  • Athena Diagnostics, Inc.
  • Taconic Biosciences, Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.